INT222549

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pomc, Gnrh1) extracellular region (Pomc, Gnrh1) molecular_function (Pomc, Gnrh1)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
lactotrophs 1
Pomc (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 22 82.00 Quite High
Neuropeptide 5 73.44 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 4 41.76 Quite Low
Adenoma 5 30.72 Quite Low
Targeted Disruption 22 16.16 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A crucial experiment still lacking is to determine whether N-POMC is a mediator of the action of GnRH on lactotrophs by investigating whether the GnRH effect can be blocked by treatment with an anti-N-POMC antiserum.
N-POMC Spec (whether) Positive_regulation (mediator) of GnRH in lactotrophs
1) Confidence 0.13 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.12

General Comments

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