INT222561

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gnrh1, Prl) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
plasma 1
pituitary 1
Gnrh1 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 10 97.70 Very High Very High Very High
agonist 44 92.04 High High
antagonist 78 86.64 High High
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Dopamine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 2 90.24 High High
Galactorrhea 4 82.76 Quite High
Obesity 8 80.96 Quite High
Adenoma 10 69.92 Quite High
Targeted Disruption 44 55.36 Quite High
Klinefelter Syndrome 2 39.84 Quite Low
Stress 96 5.00 Very Low Very Low Very Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, neuropeptide Y (NPY) can mimic the action of GnRH on lactotroph mitosis in pituitary cell aggregates (116) but it inhibits the stimulation of PRL mRNA by GnRH (118).
GnRH Positive_regulation (stimulation) of PRL mRNA in pituitary associated with neuropeptide
1) Confidence 0.15 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.21 Pain Relevance 0.14
Some investigators found GnRH to increase plasma PRL concentrations in normal women during the follicular (127) and luteal phase (133) of the cycle and in postmenopausal women (131), whereas others found that the response was significantly greater in the luteal phase and in progesterone-treated menopausal women compared to women in early follicular phase (132).
GnRH Positive_regulation (increase) of PRL in plasma associated with endometriosis (extended)
2) Confidence 0.13 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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