INT222588

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 7.93
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1) cytoplasm (Thbs1)
Anatomy Link Frequency
astrocytes 14
Spine 4
brains 2
Thbs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 32 70.24 Quite High
antagonist 39 27.40 Quite Low
agonist 22 26.12 Quite Low
imagery 20 21.52 Low Low
Gabapentin 10 20.08 Low Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1211 99.84 Very High Very High Very High
Cancer 32 99.36 Very High Very High Very High
Stress 88 98.08 Very High Very High Very High
Apoptosis 11 97.00 Very High Very High Very High
Cognitive Disorder 40 79.44 Quite High
Stroke 20 72.20 Quite High
Pituitary Cancer 11 68.36 Quite High
Generaliased Trisomy 10 63.96 Quite High
Intellectual Impairment 30 59.80 Quite High
Parkinson's Disease 40 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that soluble TSP-1 modulates spine morphology and that reduced expression of TSP-1 in DS astrocytes leads to abnormal spine development.


Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in astrocytes associated with syndrome
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.18 Pain Relevance 0
Quantification of TSP-1 protein levels by ELISA demonstrated significant reductions in both DS astrocyte cell lysates and CM (Figure 3E), suggesting that reduced TSP-1 expression leads to decreased TSP-1 in DS CM.
Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in astrocyte associated with syndrome
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.90 Pain Relevance 0
Spine and synaptic alterations were associated with reduced expression of TSP-1, which was also significantly reduced in DS brains.
Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in Spine associated with syndrome
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.89 Pain Relevance 0.03
Spine and synaptic alterations were associated with reduced expression of TSP-1, which was also significantly reduced in DS brains.
Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in Spine associated with syndrome
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.89 Pain Relevance 0.04
To establish whether reduced expression of TSP-1 in DS astrocytes was associated with oxidative stress and/or energy deficits in DS cells, we analyzed the effect of free radical scavengers, antioxidants, and energy substrates on TSP-1 expression.
Spec (whether) Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in astrocytes associated with stress and syndrome
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.16 Pain Relevance 0
For some experiments, the following compounds (purchased from Sigma, St Louis, MO) were added to pure astrocyte cultures, and TSP-1 levels were determined after 24 hr: s-PBN (100 mM), Trolox (100 ┬ÁM), resveratrol (100 mM), nicotinamide (15 mM), nicotinamide adenine dinucleotide (?
Spec (determined) Negative_regulation (determined) of Gene_expression (levels) of TSP-1 in astrocyte
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
Reduced TSP-1 levels in DS astrocytes and DS brains
Negative_regulation (Reduced) of Gene_expression (levels) of TSP-1 in astrocytes associated with syndrome
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.67 Pain Relevance 0
We also show that thrombospondin 1 (TSP-1), an astrocyte-secreted protein, possesses a potent modulatory effect on spine number and morphology, and that both DS brains and DS astrocytes exhibit marked deficits in TSP-1 protein expression.
Negative_regulation (marked) of Gene_expression (expression) of TSP-1 in brains associated with syndrome
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996288 Disease Relevance 1.03 Pain Relevance 0
Quantification of TSP-1 protein levels by ELISA demonstrated significant reductions in both DS astrocyte cell lysates and CM (Figure 3E), suggesting that reduced TSP-1 expression leads to decreased TSP-1 in DS CM.
Negative_regulation (reduced) of Gene_expression (expression) of TSP-1 in astrocyte associated with syndrome
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.90 Pain Relevance 0
Antioxidants and mitochondrial cofactors have no effect on TSP-1 expression and secretory deficits in DS astrocytes
Negative_regulation (deficits) of Gene_expression (expression) of TSP-1 in astrocytes associated with syndrome
10) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.01 Pain Relevance 0
These data suggest that oestrogen-induced tumour growth may be promoted by down-regulation of locally produced anti-angiogenic TSP-1.


Negative_regulation (regulation) of Gene_expression (produced) of TSP-1 associated with cancer
11) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.29 Pain Relevance 0

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