INT222624

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 15
Disease Relevance 8.42
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1) cytoplasm (Thbs1)
Anatomy Link Frequency
astrocytes 4
spine 2
brain 2
neuronal 1
Thbs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 36 89.08 High High
Gabapentin 14 38.92 Quite Low
antagonist 39 27.40 Quite Low
agonist 22 26.12 Quite Low
imagery 28 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1695 99.84 Very High Very High Very High
Cancer 36 99.36 Very High Very High Very High
Congenital Anomalies 56 97.82 Very High Very High Very High
Cognitive Disorder 56 92.60 High High
Generaliased Trisomy 14 82.80 Quite High
Stroke 28 82.40 Quite High
Alzheimer's Dementia 28 80.64 Quite High
Neurodegenerative Disease 14 79.60 Quite High
Parkinson's Disease 56 74.24 Quite High
Pituitary Cancer 11 68.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling in DS astrocytes may lead to a downregulation of TSP-1 protein levels.
Negative_regulation (downregulation) of TSP-1 in astrocytes associated with syndrome
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.96 Pain Relevance 0.04
Lastly, the loss of thrombospondins also leads to craniofacial dysmorphism [83], which is a common feature of DS subjects and DS mouse models [84], [85], raising the possibility that reduced TSP-1 levels may be associated with a number of developmental anomalies present in DS.
Negative_regulation (reduced) of TSP-1 associated with syndrome and congenital anomalies
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.77 Pain Relevance 0
To determine whether depletion of TSP-1 is sufficient to alter spine number and morphology, NL astrocyte/hippocampal neuron cocultures were treated with anti-TSP-1 antibody to neutralize the endogenous TSP-1 secreted by NL human astrocytes.
Spec (whether) Negative_regulation (depletion) of TSP-1 in astrocytes
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.12 Pain Relevance 0
Recombinant TSP-1 was added to the culture medium at day 7, and fresh TSP-1 was replenished every 3 days for 14 days.
Negative_regulation (replenished) of TSP-1
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.67 Pain Relevance 0
Indeed, reduced TSP-1 activity in cocultures of NL astrocytes is sufficient to dramatically alter spine morphology (Figure 5) and synapse formation (data not shown) in hippocampal neurons.
Negative_regulation (reduced) of TSP-1 in spine
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.52 Pain Relevance 0
TSP-1 levels were markedly reduced in DS astrocytes and brain homogenates, and restoration of TSP-1 levels prevented spine and synaptic alterations.
Negative_regulation (reduced) of TSP-1 in astrocytes associated with syndrome
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.99 Pain Relevance 0
TSP-1 levels were reduced in both DS astrocyte homogenates and CM, as well as in DS fetal brains, raising the possibility that in DS, TSP-1 deficits could affect critical stages of neuronal development such as neurite outgrowth [28]–[30], [79], neuronal migration [32], or synaptogenesis [20], [80].
Negative_regulation (reduced) of TSP-1 in neuronal associated with syndrome
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.42 Pain Relevance 0
Reduced TSP-1 levels in DS astrocytes and DS brains
Negative_regulation (Reduced) of TSP-1 in astrocytes associated with syndrome
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.67 Pain Relevance 0
Depletion of TSP-1 from normal astrocytes resulted in dramatic changes in spine morphology, while restoration of TSP-1 levels prevented DS astrocyte-mediated spine and synaptic alterations.
Negative_regulation (Depletion) of TSP-1 in spine associated with syndrome
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996288 Disease Relevance 1.02 Pain Relevance 0
A comparison of TSP-1 protein expression in fetal brain lysates showed an average reduction of 57.9% in TSP-1 levels in DS brains despite the average age of DS brain samples being almost 4 weeks younger than the average age of NL brain samples (Figure 3F). qPCR analysis of mRNA expression indicated similar mRNA levels in DS brains than in NL brains for all thrombospondin isoforms (TSP-1, -2, -3 and -4)(Figure S2), suggesting that a post transcriptional mechanism underlies the changes observed in TSP-1 in DS brains and astrocyte cultures.


Negative_regulation (reduction) of TSP-1 in brains associated with syndrome
10) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.89 Pain Relevance 0
At day 7, anti-TSP-1 was added to the cultures and replenished every 3 days during 14 days.
Negative_regulation (replenished) of TSP-1
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.12 Pain Relevance 0
1000 Calbiochem, Gibbstown, NJ) was added to the cultures, and fresh anti-TSP-1 was replenished with partial medium changes every 3 days.
Negative_regulation (replenished) of TSP-1
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
Depletion of TSP-1
Negative_regulation (Depletion) of TSP-1
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
TSP-1 levels were markedly reduced in DS astrocytes and brain homogenates, and restoration of TSP-1 levels prevented spine and synaptic alterations.
Negative_regulation (reduced) of TSP-1 in brain associated with syndrome
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.99 Pain Relevance 0
These data suggest that oestrogen-induced tumour growth may be promoted by down-regulation of locally produced anti-angiogenic TSP-1.


Negative_regulation (regulation) of TSP-1 associated with cancer
15) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.29 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox