INT222633

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

cytoplasm (Acvr2a)

Acvr2a (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 44 36.60 antagonist 78 35.20 Nerve growth factor 56 5.00 Inflammation 54 5.00 cytokine 44 5.00 Calcitonin gene-related peptide 34 5.00 substance P 32 5.00 gABA 30 5.00 Dopamine 26 5.00 Glutamate 24 5.00

Disease Link Frequency Relevance Heat Stress 96 5.00 INFLAMMATION 56 5.00 Cancer 44 5.00 Targeted Disruption 44 5.00 Pituitary Cancer 22 5.00 Starvation 20 5.00 Rheumatoid Arthritis 16 5.00 Natriuresis 14 5.00 Adhesions 12 5.00 Hyperplasia 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

mRNA levels were as low as in the mice with only the Act-R-II gene disrupted and the absence of inhibin increased serum FSH levels both in the presence and absence of the Act-R-II (474).

Negative_regulation (disrupted) of Act-R-II

1) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

mRNA levels were as low as in the mice with only the Act-R-II gene disrupted and the absence of inhibin increased serum FSH levels both in the presence and absence of the Act-R-II (474).

Negative_regulation (absence) of Act-R-II

2) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

General Comments

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