INT222645

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.77
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 1
Astrocytes 1
Col4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Demyelination 47 95.60 Very High Very High Very High
metalloproteinase 8 81.20 Quite High
Multiple sclerosis 25 63.12 Quite High
Inflammation 42 54.56 Quite High
Central nervous system 6 50.00 Quite Low
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 78 95.60 Very High Very High Very High
Adhesions 6 81.64 Quite High
Gliosis 3 78.24 Quite High
Pituitary Cancer 11 74.08 Quite High
Pallor 1 67.40 Quite High
INFLAMMATION 40 54.56 Quite High
Cancer 23 23.60 Low Low
Disease 6 23.16 Low Low
Neuromyelitis Optica 31 19.36 Low Low
Prolactinoma 2 11.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the pituitary, laminin affects PRL and gonadotrophin secretion and collagen IV has been reported to affect the release of prolactin (825).
Localization (secretion) of collagen IV in pituitary
1) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.16 Pain Relevance 0.14
In addition, there is profound precipitation of collagen IV on the surface of reactive astrocytes (g). h–n Astrocytes in a chronic expanding lesion following pattern II demyelination [24].
Localization (precipitation) of collagen IV in Astrocytes associated with demyelination
2) Confidence 0.03 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.61 Pain Relevance 0.23

General Comments

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