INT222649

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.21
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
anterior pituitary 1
Gria3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 6 100.00 Very High Very High Very High
Glutamate 14 98.48 Very High Very High Very High
depression 3 96.80 Very High Very High Very High
Neurotransmitter 8 92.80 High High
long-term potentiation 6 77.60 Quite High
nMDA receptor 17 73.20 Quite High
Peripheral nervous system 1 70.12 Quite High
gABA 15 66.32 Quite High
antagonist 40 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 3 96.80 Very High Very High Very High
Hypoxia 146 61.84 Quite High
Injury 5 50.00 Quite Low
Adenoma 5 40.88 Quite Low
Carpal Tunnel Syndrome 4 23.52 Low Low
Attention Deficit Hyperactivity Disorder 1 17.08 Low Low
Sprains And Strains 1 12.40 Low Low
Stress 53 6.92 Low Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found 22 of these genes were represented on our focused array (GPR51, GRIA3, GRIA4, GRID2, GRIK 1, GRIK3, GRIK4, GRIN1, GRIN2A GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, and GUCY2F).
Localization (array) of GRIA3
1) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.10
While they do report significant decreases in GluR2 and GluR3 subunits, there are no significant changes in GluR1 expression (see Supplementary Material Figure 4a; Wright et al., 2008).
Localization (decreases) of GluR3
2) Confidence 0.12 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.10 Pain Relevance 0.13
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Localization (release) of GluR3 in anterior pituitary associated with glutamate and glutamate receptor
3) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.62

General Comments

This test has worked.

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