INT222650

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.84
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 2
endothelial cells 1
pancreas 1
nervous tissue 1
basal lamina 1
Col4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 35 94.20 High High
Calcium channel 6 77.28 Quite High
Sciatic nerve 23 50.00 Quite Low
Kinase C 4 48.88 Quite Low
Inflammation 69 45.28 Quite Low
fibrosis 45 43.20 Quite Low
antagonist 83 28.60 Quite Low
withdrawal 8 12.48 Low Low
Nerve growth factor 57 5.00 Very Low Very Low Very Low
agonist 47 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 15 100.00 Very High Very High Very High
Diabetes Mellitus 31 98.52 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 96.24 Very High Very High Very High
Pancreatitis 57 94.20 High High
Hypertension 36 87.60 High High
Immunization 17 86.48 High High
Foreign-body Reaction 1 84.88 Quite High
Hypertrophy 12 78.44 Quite High
Foreign Bodies 1 74.72 Quite High
Stress 109 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collagen IV, one of the main components of the basal lamina in nervous tissue, was found in noticeable amounts and evenly distributed throughout the implant lumens in treated animals.
Gene_expression (found) of Collagen IV in nervous tissue
1) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2358889 Disease Relevance 0.23 Pain Relevance 0
Further, the collagen type I maintaining tissue structure and collagen type IV, a component of basal lamina that allows interaction with integrins and favors cell adhesion, were increased expressed.
Gene_expression (expressed) of collagen type IV in basal lamina associated with adhesions
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.40 Pain Relevance 0.04
On the other hand, in the control rats, type IV collagen deposition was observed as continuous lines along the BM of the ducts [35], as has been found in the normal rat [11, 22] and normal human pancreas [36, 37].
Gene_expression (deposition) of type IV collagen in pancreas
3) Confidence 0.08 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.52 Pain Relevance 0.15
In the rat pituitary, laminin, the HSPG perlecan, and type IV collagen. are found inside nonhormonal cells whereas laminin and, to a lesser extent, type IV collagen are found in hormonal cells, suggesting that hormonal cells participate to the elaboration of BM (822).
Gene_expression (found) of type IV collagen in pituitary
4) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
In the rat pituitary, laminin, the HSPG perlecan, and type IV collagen. are found inside nonhormonal cells whereas laminin and, to a lesser extent, type IV collagen are found in hormonal cells, suggesting that hormonal cells participate to the elaboration of BM (822).
Gene_expression (found) of type IV collagen in pituitary
5) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
Interestingly, Roy showed a shift of gene expression towards collagen IV and fibronectin expression in vitro (endothelial cells) and in diabetic rats (kidney cortex and myocardium) [15] with a similar design of a period with poor control followed by normalized glucose levels.
Gene_expression (expression) of collagen IV in endothelial cells associated with diabetes mellitus
6) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946275 Disease Relevance 0.69 Pain Relevance 0

General Comments

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