INT222655

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Sdc1) cell adhesion (Sdc1) protein complex (Sdc1)
cell-cell signaling (Sdc1) cytoplasm (Sdc1)
Sdc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 44 99.02 Very High Very High Very High
metalloproteinase 16 82.12 Quite High
cerebral cortex 2 58.96 Quite High
antagonist 78 5.00 Very Low Very Low Very Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 55 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 13 99.56 Very High Very High Very High
Cancer 47 83.60 Quite High
Prolactinoma 4 71.88 Quite High
Pituitary Cancer 22 70.72 Quite High
Stress 96 5.00 Very Low Very Low Very Low
INFLAMMATION 57 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are both agonists at the EGF-R, but the former and not the latter binds to HSPG present in the extracellular microenvironment; consequently, the dynamics of the same cell through the same EGF-R will be different when stimulated with TGF-?
HSPG Neg (not) Binding (binds) of associated with agonist
1) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
Importantly, cell surface HSPG is a necessary coreceptor, interacting with the carboxyl-terminal domain.
HSPG Binding (interacting) of
2) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.54 Pain Relevance 0.07
They are the only HSPGs that penetrate the cytoplasm, thus allowing for interaction with the cytoskeleton (syndecan-1) or focal adhesion molecules (syndecan-4).
syndecan-1 Binding (interaction) of associated with adhesions
3) Confidence 0.04 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.10 Pain Relevance 0

General Comments

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