INT222660

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 5.31
Pain Relevance 12.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
spinal cord 3
dorsal horn 3
horn 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 190 99.84 Very High Very High Very High
spinal dorsal horn 90 99.84 Very High Very High Very High
Ultiva 550 99.70 Very High Very High Very High
Dorsal horn 100 99.68 Very High Very High Very High
long-term potentiation 60 99.32 Very High Very High Very High
Hyperalgesia 390 99.22 Very High Very High Very High
Perioperative pain 50 97.96 Very High Very High Very High
opiate 20 97.84 Very High Very High Very High
central sensitization 90 97.46 Very High Very High Very High
ketamine 350 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 460 99.22 Very High Very High Very High
Nociception 60 99.06 Very High Very High Very High
Post Operative Pain 50 97.96 Very High Very High Very High
INFLAMMATION 48 96.96 Very High Very High Very High
Pain 60 96.44 Very High Very High Very High
Neuropathic Pain 90 95.52 Very High Very High Very High
Hypersensitivity 10 71.00 Quite High
Hyperplasia 6 50.80 Quite High
Cancer Pain 10 7.80 Low Low
Stress 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of these cells with the receptor tyrosine kinase inhibitor herbimycin A, markedly reduced basal PRL mRNA levels in a reversible manner, as well as Tyr phosphorylation, and inhibited PRL mRNA gene expression induced by bFGF and TRH (388).
Phosphorylation (phosphorylation) of Tyr
1) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0
NMDA: N-methyl-D-aspartate; NR2B: N-Methyl-D-Aspartate receptor 2B subunit; Py-NR2B: tyrosine phosphorylation of NR2B; Tyr-1472: tyrosine 1472; LTP: long-term potentiation.


Phosphorylation (phosphorylation) of Tyr-1472 associated with long-term potentiation
2) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.16 Pain Relevance 0.92
NMDA: N-methyl-D-aspartate; NR2B: N-Methyl-D-Aspartate receptor 2B subunit; Py-NR2B: tyrosine phosphorylation of NR2B; Tyr-1472: tyrosine 1472; LTP: long-term potentiation.


Phosphorylation (phosphorylation) of Tyr-1472 associated with long-term potentiation
3) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.16 Pain Relevance 0.92
Our study reports for the first time in an vivo model of hyperalgesia induced by remifentanil that tyrosine phosphorylation of NR2B at Tyr1472 in spinal dorsal horn plays a key role in hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of Tyr1472 in dorsal horn associated with hyperalgesia, spinal dorsal horn and ultiva
4) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.83 Pain Relevance 1.88
In a rat model of postoperative pain, using immunohistochemistry and immunoblotting, we tested this hypothesis through examining tyrosine phosphorylation of NR2B subunit at Tyr1472 in the superficial spinal cord after intraoperative infusion of remifentanil with or without pretreatment of ketamine.


Phosphorylation (phosphorylation) of Tyr1472 in spinal cord associated with ketamine, ultiva, perioperative pain and spinal cord
5) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.35 Pain Relevance 1.32
It has been reported that tyrosine phosphorylation of the NR2B at Tyr1472 in the spinal dorsal horn contribute to the development of hyperalgesia in inflammation pain model, as well as neuropathic pain model [30,33].
Phosphorylation (phosphorylation) of Tyr1472 in dorsal horn associated with pain, hyperalgesia, inflammation, spinal dorsal horn and neuropathic pain
6) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.81 Pain Relevance 1.21
Moreover, suggestion that the mechanisms of central sensitization induced by opiates share some common pathways with those induced by nociceptive inputs [34] led us to speculate that tyrosine phosphorylation of the NR2B subunit at Tyr1472 in spinal cord may be involved in the hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of Tyr1472 in spinal cord associated with nociception, hyperalgesia, central sensitization, ultiva, opiate and spinal cord
7) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.71 Pain Relevance 1.34
This study provides direct evidence that tyrosine phosphorylation of the NR2B at Tyr1472 in spinal dosal horn contributes to postoperative hyperalgesia induced by remifentanil and supports the potential therapeutic value of ketamine for improving postoperative hyperalgesia induced by remifentanil.



Phosphorylation (phosphorylation) of Tyr1472 in horn associated with hyperalgesia, ketamine and ultiva
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2809057 Disease Relevance 0.75 Pain Relevance 1.69
To quantificate the expression of NR2B phosphorylation at Tyr-1472 in the dorsal horn during the maintenance of hyperalgesia induced by remifentanil, western blot studies were performed.
Phosphorylation (phosphorylation) of Tyr-1472 in dorsal horn associated with hyperalgesia, dorsal horn and ultiva
9) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.15 Pain Relevance 0.97
Tyr-1472 phosphorylation is important for synaptic plasticity and plays a role in the induction of LTP [31], which shares pharmacology and signal transduction pathways with OIH [32].
Phosphorylation (phosphorylation) of Tyr-1472 associated with hyperalgesia and long-term potentiation
10) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.76 Pain Relevance 1.07
Immunocytochemical localization and expression of NR2B phosphorylation at Tyr-1472 in spinal cord
Phosphorylation (phosphorylation) of Tyr-1472 in spinal cord associated with spinal cord
11) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.57 Pain Relevance 0.99

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