INT22270

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Context Info
Confidence 0.39
First Reported 1990
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 3.56
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGKV1-5)
Anatomy Link Frequency
neurons 2
dorsal 1
brains 1
posterior 1
cortex 1
IGKV1-5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 64 100.00 Very High Very High Very High
primary somatosensory cortex 50 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
agonist 5 99.96 Very High Very High Very High
Morphine 14 99.80 Very High Very High Very High
opiate 6 99.54 Very High Very High Very High
antagonist 4 99.48 Very High Very High Very High
antinociception 10 99.20 Very High Very High Very High
Spinal cord 2 97.80 Very High Very High Very High
Catecholamine 3 86.16 High High
Disease Link Frequency Relevance Heat
Ocular Hypertension 142 99.68 Very High Very High Very High
Epilepsy 56 99.00 Very High Very High Very High
Optic Nerve Injuries 70 98.52 Very High Very High Very High
Pressure Volume 2 Under Development 3 98.24 Very High Very High Very High
Frailty 8 96.72 Very High Very High Very High
Ganglion Cysts 21 95.96 Very High Very High Very High
Cognitive Disorder 12 95.88 Very High Very High Very High
Coronary Vasospasm 1 94.28 High High
Increased Venous Pressure Under Development 1 91.92 High High
Injury 23 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine exposure affects the visual response properties of V1 neurons in cat.
Regulation (affects) of V1 in neurons associated with morphine
1) Confidence 0.39 Published 2005 Journal Brain Res. Section Title Doc Link 16212946 Disease Relevance 0 Pain Relevance 0.86
In view of the localization of opiate receptors in mammalian visual system, chronic opiate exposure is likely to affect the visual responses properties of V1 neurons.
Spec (likely) Regulation (affect) of V1 in neurons associated with opiate
2) Confidence 0.39 Published 2005 Journal Brain Res. Section Abstract Doc Link 16212946 Disease Relevance 0 Pain Relevance 0.73
To some extent, this was to be expected because area V1 is known to be sensitive to low-level image features, such as luminance and contrast, which we kept constant throughout the recordings (see Methods).
Regulation (sensitive) of V1
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
As in area V1 little, if any, magnification factor change is seen outside the LPZs in areas V2, V3.
Neg (little) Regulation (change) of V1
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
By contrast, results describing the function of visual areas V2 and V3 after long-standing V1 lesions are limited: 1) there are no electrophysiological studies addressing directly this issue in monkeys, and 2) neuroimaging studies of human “blindsight” patients have not produced definitive results: On the one hand, the fMRI study of hemianopic patients FS and GY by Goebel et al., appears to confirm results from primate electrophysiology suggesting that visually driven activity in areas V2, V3 is strictly dependent on V1 input [29].
Regulation (dependent) of V1
5) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
There is excellent overlap of the eccentricity versus distance curves in foveal V1, outside the area of the lesion, suggesting that the magnification factor remains unchanged in nearby V1 cortex following the lesion.
Neg (unchanged) Regulation (unchanged) of V1 in cortex
6) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
To examine the influence of the V1 lesion on V2 and V3 activity, we identified retinotopically the V1-lesion projection zones (LPZ) in these areas (i.e. we selected the regions in dorsal V2, V3 that in pre-lesion retinotopy contain the same eccentricity information as the V1 area to be lesioned).
Spec (examine) Regulation (influence) of V1 in dorsal
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
To investigate the effects of small gyrification pattern on reaction-diffusion waves, the 3D form of V1 and its retinotopic map was obtained by fMRI from a migraineur (PVV) who has made precise perimetric recordings of his visual aura [43].
Spec (investigate) Regulation (effects) of V1 associated with epilepsy
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659426 Disease Relevance 0.28 Pain Relevance 0
The 4,800 probes on this 16S rRNA gene tiling array consist of sets of three 18–30 nt long overlapping oligonucleotides targeting the V1 and V6 region sequences from 1,140 phylotypes, respectively.
Regulation (targeting) of V1
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725325 Disease Relevance 0.05 Pain Relevance 0.05
To investigate whether the retinotopic organization of areas V1, V2, V3 is changed (e.g. reorganized) after V1 lesioning, we compared visual eccentricity versus cortical distance plots (Materials and Methods) across these areas both in the lesioned and the intact hemispheres.
Regulation (changed) of V1
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Since (1) bilateral lesions of the spinal cord dorsolateral funiculus (DLF) were shown in the current study to abolish phenylephrine antinociception, (2) PVH is known to send vasopressinergic projections to the spinal cord via the DLF, and (3) intrathecal vasopressin produces antinociception via V1-like vasopressin receptors, the effect of an intrathecal V1 vasopressin antagonist was tested on phenylephrine-induced antinociception.
Regulation (effect) of V1 in DLF associated with antinociception, antagonist, intrathecal and spinal cord
11) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2271928 Disease Relevance 0.22 Pain Relevance 1.11
Future large-scale randomized, controlled clinical trials are warranted to evaluate the role of V1 agonists in the treatment of perioperative hypotension in more detail.
Regulation (role) of V1 associated with pressure volume 2 under development and agonist
12) Confidence 0.02 Published 2008 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 18683482 Disease Relevance 0.52 Pain Relevance 0.39
Interestingly, however, in our study there was no measurable microglial response in the LGN or V1 of the OHT brains even after durations as long as 58 days post elevated IOP.
Neg (no) Regulation (response) of V1 in brains associated with ocular hypertension
13) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.61 Pain Relevance 0.06
MAC-1 immunoreactivity was at background levels in the LGN (Figure 3C and Figure 5A) and V1 (Figure 4C) of the animals with unilateral OHT.
Regulation (immunoreactivity) of V1 associated with ocular hypertension
14) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.78 Pain Relevance 0.03
Hence, whether color can interfere with orientation or vice versa depends on the relative levels of V1 responses to these two feature types.
Regulation (responses) of V1
15) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1847698 Disease Relevance 0 Pain Relevance 0
Here we investigate whether rhythmic activity in V1 of the macaque monkey (macaca mulatta) is affected by top-down visual attention.
Spec (whether) Regulation (affected) of V1
16) Confidence 0.01 Published 2010 Journal Neuron Section Abstract Doc Link PMC2923752 Disease Relevance 0.10 Pain Relevance 0
Arrays targeting HP, S1, and V1 (Figure 1C) were centered on the following stereotaxic coordinates on the left hemisphere, in mm from Bregma with respect to the antero-posterior (AP), medio-lateral (ML), and dorso-ventral (DV) axes (Paxinos and Watson, 1997): HP (AP: ?
Regulation (targeting) of V1 in posterior associated with primary somatosensory cortex and hippocampus
17) Confidence 0.01 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.31

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