INT22274

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.32
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TBXA2R) signal transducer activity (TBXA2R)
Anatomy Link Frequency
platelet 10
blood 2
plasma 2
TBXA2R (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 51 99.84 Very High Very High Very High
Inflammation 54 96.48 Very High Very High Very High
Angina 3 96.16 Very High Very High Very High
Analgesic 6 94.76 High High
COX-2 inhibitor 16 90.16 High High
adenocard 3 88.96 High High
cINOD 95 88.00 High High
Potency 8 77.80 Quite High
agonist 7 68.96 Quite High
analgesia 2 61.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 78 96.48 Very High Very High Very High
Pre-eclampsia 34 96.48 Very High Very High Very High
Cv General 3 Under Development 3 96.16 Very High Very High Very High
Leukemia 1 95.60 Very High Very High Very High
Myocardial Infarction 16 91.12 High High
Disease 75 90.88 High High
Stroke 7 89.04 High High
Hemorrhage 14 86.00 High High
Coagulation Disorder 8 78.28 Quite High
Cardiovascular Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulate TXA2 synthesis and A23187-stimulated TXA2 synthesis was only marginally inhibited by concentrations of ibuprofen and indomethacin that inhibited 45Ca2+ uptake by 50%.
Negative_regulation (inhibited) of Gene_expression (synthesis) of TXA2
1) Confidence 0.58 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2272350 Disease Relevance 0.09 Pain Relevance 0.28
Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulate TXA2 synthesis and A23187-stimulated TXA2 synthesis was only marginally inhibited by concentrations of ibuprofen and indomethacin that inhibited 45Ca2+ uptake by 50%.
Negative_regulation (inhibited) of Gene_expression (synthesis) of TXA2
2) Confidence 0.43 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2272350 Disease Relevance 0.09 Pain Relevance 0.28
In low-dose acetylsalicylic acid is used to block production of thromboxane A2.
Negative_regulation (block) of Gene_expression (production) of thromboxane A2 associated with aspirin
3) Confidence 0.38 Published 2001 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 11757226 Disease Relevance 0.40 Pain Relevance 0.39
N-Carboxy-3-morpholinosydnone imine ethyl ester (molsidomine) and its main metabolite 3-morpholinosydnone imine (SIN-1) were investigated in rabbit platelet-rich plasma (PRP) for antiaggregatory activity and inhibition of thromboxane A2 (TXA2) generation (arachidonic acid (AA)-induced) as well as in human PRP regarding prostaglandin endoperoxide analogue (U-46 619)- and AA-induced aggregation and TXB2 formation.
Negative_regulation (inhibition) of in PRP Gene_expression (generation) of TXA2 in plasma
4) Confidence 0.33 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 6896278 Disease Relevance 0 Pain Relevance 0.03
In our simulation, as aspirin strongly inhibited the production of TXA2, the value of PGI2/TXA2 was much larger than before the administration of medicine.
Negative_regulation (inhibited) of Gene_expression (production) of TXA2 associated with aspirin
5) Confidence 0.33 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.65 Pain Relevance 0.70
The i.v. administration of LY315920, 5 min before harvesting the bronchoalveolar lavage cells, resulted in the inhibition of sPLA2-induced production of TXA2 with an ED50 of 16.1 mg/kg.
Negative_regulation (inhibition) of Gene_expression (production) of TXA2
6) Confidence 0.23 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.15 Pain Relevance 0.14
Platelet thromboxane A2 (TXA2) production in response to arachidonic acid was reduced in all three patients, i.e. 11.7, 4.6 and 4.4 ng TXB2/3 x 10(8) plt respectively (normal range was 49-81 ng/3 x 10(8) plt), whereas they were normal in response to exogenous PGH2, i.e. 71.4, 56.6 and 48.9 ng/3 x 10(8) respectively (normal range 49-85 ng/3 x 10(8) plt).
Negative_regulation (reduced) of Gene_expression (production) of TXA2 in Platelet
7) Confidence 0.12 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8562397 Disease Relevance 0.39 Pain Relevance 0.17
Furthermore, aspirin failure may be due to enhanced formation of vasoactive and/or proaggregatory eicosanoids despite an almost complete suppression of platelet TXA2 biosynthesis by aspirin.
Negative_regulation (suppression) of Gene_expression (biosynthesis) of TXA2 in platelet associated with aspirin
8) Confidence 0.05 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592549 Disease Relevance 0.26 Pain Relevance 0.46
In contrast, inhibition of TXA2-dependent platelet function in vivo occurs when platelet COX-1-dependent capacity to synthesize TXA2 (as assessed by measuring serum TXB2 levels) is reduced ?
Negative_regulation (reduced) of Gene_expression (synthesize) of TXA2 in platelet
9) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.33 Pain Relevance 0.39
In fact, a non-linear relationship of inhibition of platelet TXA2 generation with inhibition of TXA2-mediated platelet aggregation has been found (Sciulli et al 2006).
Negative_regulation (inhibition) of Gene_expression (generation) of TXA2 in platelet
10) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.26 Pain Relevance 0.36
Following the discovery that prostacyclin and thromboxane levels are disturbed in the maternal circulation in preeclampsia, a number of centers have performed clinical trials with low dose aspirin, believing that treatment with cyclooxygenase inhibitors could prevent or ameliorate the disorder by reducing platelet TXA2 production while sparing endothelial PGI2 synthesis.
Negative_regulation (reducing) of Gene_expression (production) of TXA2 in platelet associated with aspirin and pre-eclampsia
11) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.54 Pain Relevance 0.05
The compound inhibits the production of thromboxane B2 (TxB2) in Ca++ ionophore A-23187-stimulated human peripheral blood leukocytes (HPBL; IC50 = 0.01 microM) and human whole blood (IC50 = 0.08 microM) and is a potent inhibitor of epinephrine-induced human platelet aggregation (IC50 = 0.045 microM).
Negative_regulation (inhibits) of Gene_expression (production) of thromboxane B2 in blood
12) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996452 Disease Relevance 0.17 Pain Relevance 0.04

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