INT222742

Context Info Confidence 0.53 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 9 Disease Relevance 12.09 Pain Relevance 3.03

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12) cytoplasm (S100A12)

S100A12 (Homo sapiens)

Pain Link Frequency Relevance Heat psoriasis 2 99.84 corticosteroid 12 99.82 Crohn's disease 210 99.00 Inflammatory marker 26 97.92 spastic colon 144 95.64 Infliximab 6 94.32 Inflammation 170 93.20 Piles 6 90.96 Osteoarthritis 4 81.36 Arthritis 4 79.92

Disease Link Frequency Relevance Heat Psoriasis 4 99.84 Inflammatory Bowel Disease 500 99.68 Disease 446 99.54 Ileitis 6 99.48 Skin Cancer 5 99.28 Colitis 14 98.88 INFLAMMATION 182 97.60 Melanoma 39 97.20 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 126 95.64 Nicotine Addiction 78 94.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This result is partly in accordance with an earlier study in which corticosteroids did not alter significantly S100A12 serum levels of IBD adults [8].

Neg (not) Regulation (alter) of S100A12 associated with inflammatory bowel disease and corticosteroid

1) Confidence 0.53 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.75 Pain Relevance 0.31

Similarly, all treatment modalities, leading to a subsequent disease remission, did not seem to have a noticeable effect on serum levels of S100A12 in the IBD group.

Regulation (effect) of S100A12 associated with inflammatory bowel disease and disease

2) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.78 Pain Relevance 0.32

Is this interaction dependant on the oligomeric state of the S100 protein?

Regulation (dependant) of S100 protein

3) Confidence 0.29 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.87 Pain Relevance 0.26

The median value of serum S100A12 levels was 68.2 ng/mL (range: 43.4-147.4) for UC patients and 70 ng/mL for CD patients (range: 41.4-169.8).

Regulation (value) of S100A12 associated with inflammatory bowel disease and crohn's disease

4) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.75 Pain Relevance 0.51

The median values of serum S100A12 levels were 68.2 ng/mL (range: 43.4-147.4) in UC, 70 ng/mL (41.4-169.8) in CD and 43.4 ng/mL (34.4-74.4) in IBS patients.

Regulation (values) of S100A12 associated with inflammatory bowel disease, crohn's disease and spastic colon

5) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.68 Pain Relevance 0.91

Similarly, by relying on S100A12 serum levels, disease location could not be predicted, despite the fact that, at first glance, patients with ileocolitis or ileitis seemed to exhibit higher values of serum S100A12, compared to those with CD colitis alone.

Regulation (values) of S100A12 associated with colitis, inflammatory bowel disease, crohn's disease, ileitis and disease

6) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.66 Pain Relevance 0.29

Both UC and CD patients with active disease seemed to have higher values of S100A12 in serum, compared to IBD subjects with inactive disease but this difference was not statistically significant.

Regulation (values) of S100A12 associated with inflammatory bowel disease, crohn's disease and disease

7) Confidence 0.23 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.12 Pain Relevance 0.21

Immunohistochemical staining of the removed tissues showed a strong positivity for S 100 protein, HMB 45 and MART-1 (Figure 3, 4, 5).

Regulation (positivity) of S 100 protein

8) Confidence 0.20 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2233626 Disease Relevance 0.50 Pain Relevance 0.03

S100A12 is up regulated in psoriasis and melanoma [101].

Regulation (regulated) of S100A12 associated with psoriasis and skin cancer

9) Confidence 0.17 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.08 Pain Relevance 0.20

General Comments

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