INT22276

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 65
Total Number 65
Disease Relevance 23.22
Pain Relevance 14.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TBXA2R) signal transducer activity (TBXA2R)
Anatomy Link Frequency
platelet 13
blood 6
PGE2 5
plasma 3
monocytes 3
TBXA2R (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 253 99.84 Very High Very High Very High
Inflammatory mediators 39 99.12 Very High Very High Very High
COX2 17 99.04 Very High Very High Very High
Angina 20 98.76 Very High Very High Very High
cINOD 342 98.64 Very High Very High Very High
Inflammation 379 98.12 Very High Very High Very High
bradykinin 32 97.92 Very High Very High Very High
COX-2 inhibitor 97 97.00 Very High Very High Very High
rheumatoid arthritis 37 96.94 Very High Very High Very High
cytokine 39 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 49 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Hypertension 27 99.86 Very High Very High Very High
Hemorrhage 69 99.74 Very High Very High Very High
Coagulation Disorder 36 99.44 Very High Very High Very High
INFLAMMATION 518 99.12 Very High Very High Very High
Thrombosis 80 99.12 Very High Very High Very High
Asthma 147 99.04 Very High Very High Very High
Malignant Neoplastic Disease 2 98.80 Very High Very High Very High
Cv General 3 Under Development 29 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulate TXA2 synthesis and A23187-stimulated TXA2 synthesis was only marginally inhibited by concentrations of ibuprofen and indomethacin that inhibited 45Ca2+ uptake by 50%.
Gene_expression (synthesis) of TXA2
1) Confidence 0.77 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2272350 Disease Relevance 0.09 Pain Relevance 0.27
Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulate TXA2 synthesis and A23187-stimulated TXA2 synthesis was only marginally inhibited by concentrations of ibuprofen and indomethacin that inhibited 45Ca2+ uptake by 50%.
Gene_expression (synthesis) of TXA2
2) Confidence 0.77 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2272350 Disease Relevance 0.08 Pain Relevance 0.26
COX, PGE2, and TBXA2R polymorphism
Gene_expression (polymorphism) of TBXA2R
3) Confidence 0.63 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.66 Pain Relevance 0.09
Therefore, it is potentially significant that production of TXA2 and PGE2 by stimulated monocytes have very different time courses.
Gene_expression (production) of TXA2 in monocytes
4) Confidence 0.63 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.36 Pain Relevance 0.23
These apparent COX-isotype dependencies of TXA2 and PGE2 synthesis can be explained by differences in the affinities of TXA synthase and PGE synthase for the common substrate, PGH2.
Gene_expression (synthesis) of TXA2 in PGE2
5) Confidence 0.63 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.33 Pain Relevance 0.25
TXA2 synthesis is immediate and dependent on cyclooxygenase Type 1 (COX-1) activity whereas PGE2 synthesis is delayed and dependent on COX-2 activity.
Gene_expression (synthesis) of TXA2 in PGE2
6) Confidence 0.63 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.35 Pain Relevance 0.23
In monocytes, cyclooxygenase type 1 (COX-1) activity appears to favor TXA2 production and COX-2 activity appears to favor PGE2 production.
Gene_expression (production) of TXA2 in PGE2
7) Confidence 0.59 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10903770 Disease Relevance 0 Pain Relevance 0.09
With small amounts of endogenously generated prostaglandin H2 (PGH2), TXA2 synthesis was greater than PGE2.
Gene_expression (synthesis) of TXA2 in PGE2
8) Confidence 0.59 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10903770 Disease Relevance 0.07 Pain Relevance 0.15
TBXA2R is a receptor for a potent bronchoconstrictor, thromboxane A2 (TBXA2), and a TBXA2R + 795T > C polymorphism could augment the bronchoconstrictive response to inhaled aspirin, possibly contributing to AIA development in the Korean population.28 The effect of increased TBXA2 production in the pathogenesis of AIA could be explained by the fact that oral aspirin administration uncouples the TBXA2-dependent negative feedback mechanisms, which may, in turn, increase the production of Cys-LTs.29 The TBXA2-dependent regulation of LTC4S activity may be an important pathophysiological mechanism in AIA.


Gene_expression (production) of TBXA2 associated with asthma and aspirin
9) Confidence 0.57 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.78 Pain Relevance 0.16
The differences in the levels of PGF2 alpha, TXA2, and LTB4 between normal and malignant tissue were not statistically significant.
Gene_expression (levels) of TXA2 associated with malignant neoplastic disease
10) Confidence 0.56 Published 1993 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8228569 Disease Relevance 1.06 Pain Relevance 0.22
In a single-blind, randomized, prospective study, we compared the effects of a single intravenous low dose (50 mg) or high dose (500 mg) of aspirin or placebo infused over a 60 min period on platelet aggregation, platelet thromboxane A2 production and whole-body prostanoid synthesis in 10 healthy male subjects by gas chromatography-tandem mass spectrometry. 3.
Gene_expression (production) of thromboxane A2 in body associated with aspirin
11) Confidence 0.53 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8504628 Disease Relevance 0.08 Pain Relevance 0.40
In low-dose acetylsalicylic acid is used to block production of thromboxane A2.
Gene_expression (production) of thromboxane A2 associated with aspirin
12) Confidence 0.52 Published 2001 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 11757226 Disease Relevance 0.40 Pain Relevance 0.39
We have studied the kinetics of PGE2 and TXA2 synthesis under conditions that rely on COX-1 or -2 activity.
Gene_expression (synthesis) of TXA2 in PGE2
13) Confidence 0.51 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10903770 Disease Relevance 0.06 Pain Relevance 0.14
Myocardial thromboxane A2 production increases in patients with pacing-induced ischaemia and correlates with a decrease in myocardial lactate extraction.
Gene_expression (production) of thromboxane A2 associated with cv unclassified under development
14) Confidence 0.48 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.39 Pain Relevance 0.14
The release of myocardial thromboxane A2 before any lactate production was observed in patients with unstable angina.
Gene_expression (production) of thromboxane A2 associated with angina
15) Confidence 0.48 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.44 Pain Relevance 0.18
N-Carboxy-3-morpholinosydnone imine ethyl ester (molsidomine) and its main metabolite 3-morpholinosydnone imine (SIN-1) were investigated in rabbit platelet-rich plasma (PRP) for antiaggregatory activity and inhibition of thromboxane A2 (TXA2) generation (arachidonic acid (AA)-induced) as well as in human PRP regarding prostaglandin endoperoxide analogue (U-46 619)- and AA-induced aggregation and TXB2 formation.
Gene_expression (generation) of thromboxane A2 in plasma
16) Confidence 0.47 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 6896278 Disease Relevance 0 Pain Relevance 0.03
N-Carboxy-3-morpholinosydnone imine ethyl ester (molsidomine) and its main metabolite 3-morpholinosydnone imine (SIN-1) were investigated in rabbit platelet-rich plasma (PRP) for antiaggregatory activity and inhibition of thromboxane A2 (TXA2) generation (arachidonic acid (AA)-induced) as well as in human PRP regarding prostaglandin endoperoxide analogue (U-46 619)- and AA-induced aggregation and TXB2 formation.
Gene_expression (generation) of TXA2 in plasma
17) Confidence 0.47 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 6896278 Disease Relevance 0 Pain Relevance 0.03
In rabbit PRP the inhibitory effects of molsidomine on aggregation and TXA2 generation were 20fold lower than that of SIN-1.
Gene_expression (generation) of TXA2 in PRP
18) Confidence 0.47 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 6896278 Disease Relevance 0 Pain Relevance 0.04
When the relative IC50 of COX inhibitors increased above 10, we observed a strong inhibition on the production of PGI2, whereas the production of TXA2 was hardly affected.
Gene_expression (production) of TXA2
19) Confidence 0.44 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.49 Pain Relevance 0.42
COX-1 is the main COX isozyme in PLT, which is responsible for the major production of TXA2 in the model.
Gene_expression (production) of TXA2
20) Confidence 0.44 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.62 Pain Relevance 0.67

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