INT222800

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.68
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FCRL4)
Anatomy Link Frequency
brain 1
FCRL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 91.28 High High
cytokine 120 66.24 Quite High
Inflammation 8 29.08 Quite Low
lidocaine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Flavivirus Infection 56 99.84 Very High Very High Very High
Viral Meningitis 16 96.92 Very High Very High Very High
Dengue 120 71.16 Quite High
Infection 528 68.60 Quite High
INFLAMMATION 8 29.08 Quite Low
Adhesions 8 10.16 Low Low
Sprains And Strains 56 5.00 Very Low Very Low Very Low
Disease 48 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 16 5.00 Very Low Very Low Very Low
Asthma 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CRD4–7-Fc did not bind to unglycosylated domain III of DV E protein produced in bacteria in ELISA experiments (data not shown).
CRD4-7-Fc Neg (not) Binding (bind) of
1) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.19 Pain Relevance 0
Binding of CRD4–7-Fc to both C6/36-grown DV2 (Figure 1C) and sE (Figure 1D) was inhibited by 2mM d-mannose, 2mM l-fucose, and to a lesser extent 2mM d-galactose, and depended on the presence of divalent cations.
CRD4-7-Fc Binding (Binding) of
2) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.32 Pain Relevance 0.07
Binding of the CRD4–7-Fc correlated with the different coating levels of these antigens as determined with an antibody against all 4 DV serotypes (Figure 1F).
CRD4-7-Fc Binding (Binding) of
3) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.15 Pain Relevance 0.04
ELISA data showed that both CRD4–7-Fc and MR-HA both bound to Japanese encephalitis virus (inactivated vaccine antigen) and tick-borne encephalitis virus (inactivated, mouse brain-grown) (data not shown).
CRD4-7-Fc Binding (bound) of in brain associated with flavivirus infection and viral meningitis
4) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.20 Pain Relevance 0.04
In addition, we tested whether CRD4–7-Fc and sMR-HA interacted with other flaviviruses.
CRD4-7-Fc Binding (interacted) of
5) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.18 Pain Relevance 0.04
CRD4–7-Fc bound to all four serotypes of DV in a dose-dependent manner (Figure 1E).
CRD4-7-Fc Binding (bound) of
6) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.18 Pain Relevance 0.05
We expanded our study of the interaction of MR with DV by demonstrating binding of CRD4-7-Fc to all four serotypes of DV.
CRD4-7-Fc Binding (binding) of
7) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.28 Pain Relevance 0.03
The specificity of MR CRD4–7-Fc binding to DV sE was further examined by blot overlay.
CRD4-7-Fc Binding (binding) of
8) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.19 Pain Relevance 0.03

General Comments

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