INT222810

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.14
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD209) cell adhesion (CD209) plasma membrane (CD209)
intracellular (CD209) cytoplasm (CD209)
Anatomy Link Frequency
ethmoid sinus 1
CD209 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 5 98.22 Very High Very High Very High
Inflammation 27 79.44 Quite High
chemokine 12 21.00 Low Low
fibrosis 2 19.68 Low Low
cytokine 38 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 186 98.76 Very High Very High Very High
Eosinophilic Esophagitis 5 97.28 Very High Very High Very High
Communicable Diseases 2 93.36 High High
Dengue 87 92.44 High High
Adhesions 6 89.48 High High
Dengue Hemorrhagic Fever 48 89.04 High High
Disease 37 84.52 Quite High
INFLAMMATION 29 79.44 Quite High
Rhinitis 62 78.92 Quite High
Eczema 31 58.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variations in the CD209 promoter (?
Positive_regulation (Variations) of CD209
1) Confidence 0.48 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 1.30 Pain Relevance 0
Comparison to the recent Stankovic et al. study [11], involving a patient population similar to ours and using more anatomically matched normal control tissue (i.e. 7 ethmoid sinus specimens of the 10 nasosinus control specimens), provided confidence because differential expression of several genes important in aspirin-sensitive aCRSwNP were also identified in our data (decreased AZGP1, STATH, and PIP and increased DC-SIGN (CD209) and POSTN; with increased POSTN expression also being observed in eosinophilic esophagitis (EE) [18]).
Positive_regulation (increased) of CD209 in ethmoid sinus associated with aspirin and eosinophilic esophagitis
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.67 Pain Relevance 0.16
The observation that antibodies to either MR or DC-SIGN can inhibit infection to such an extensive degree suggests that DV is likely to be using both MR and DC-SIGN for entry on cells that express both.
Positive_regulation (using) of DC-SIGN associated with infection
3) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.66 Pain Relevance 0
At this stage the simplest hypothesis that explains the above findings in primary cells expressing both MR and DC-SIGN is that DC-SIGN is required for DV attachment and MR for internalisation.
Positive_regulation (required) of DC-SIGN
4) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.51 Pain Relevance 0

General Comments

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