INT222811

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 8.26
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hand2, TH1L) nucleoplasm (TH1L) cell differentiation (Hand2)
DNA binding (Hand2) protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
immune system 1
Hand2 (Mus musculus)
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 99 97.98 Very High Very High Very High
Herpes zoster virus 4 89.68 High High
Catecholamine 12 85.80 High High
depression 64 80.88 Quite High
agonist 1 53.64 Quite High
Inflammation 53 51.20 Quite High
fifth nerve 4 43.40 Quite Low
Inflammatory response 5 38.40 Quite Low
Crohn's disease 4 23.64 Low Low
corticosteroid 4 13.80 Low Low
Disease Link Frequency Relevance Heat
Disease 120 100.00 Very High Very High Very High
Eye Infections 8 99.52 Very High Very High Very High
Aging 40 99.48 Very High Very High Very High
Inflammatory Bowel Disease 30 99.40 Very High Very High Very High
Stress 228 99.12 Very High Very High Very High
Uveitis 12 98.96 Very High Very High Very High
Asthma 6 98.44 Very High Very High Very High
Hypersensitivity 16 98.16 Very High Very High Very High
Viral Infection 5 97.64 Very High Very High Very High
Age-related Macular Degeneration 44 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cytokines are produced by subsets of CD4+ T-helper (Th) cells: in contrast to UC that is considered more of a TH2 response and CD that is associated with TH1 and TH17 profile [98–100].
TH2 Binding (associated) of TH1 associated with inflammatory bowel disease, disease and cytokine
1) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.79 Pain Relevance 0.12
A shift of Th1 to Th2 immunity with either aging or stress may enhance susceptibility to viral infection.
Th2 Binding (immunity) of Th1 associated with stress, aging and viral infection
2) Confidence 0.02 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 4.13 Pain Relevance 0.38
Based on the shifts from Th1 to Th2 immunity discussed earlier, it is not surprising that clinicians may note progression or exacerbation of allergic conditions with aging and stress.
Th2 Binding (immunity) of Th1 associated with stress, aging and hypersensitivity
3) Confidence 0.02 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 2.78 Pain Relevance 0.09
The immune responses in infants/neonates differ qualitatively from those of adults, with the immature immune system having a bias towards Th2 rather than Th1 immune responses, presenting a particularly relevant challenge for pediatric DV vaccination [15].
Th2 Binding (bias) of Th1 in immune system
4) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.56 Pain Relevance 0.11

General Comments

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