INT222843

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.04
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k7) plasma membrane (Map3k7) kinase activity (Map3k7)
response to stress (Map3k7) cytoplasm (Map3k7)
Map3k7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 67 95.88 Very High Very High Very High
Inflammation 102 95.48 Very High Very High Very High
rheumatoid arthritis 130 91.36 High High
cINOD 3 83.16 Quite High
Arthritis 30 67.44 Quite High
chemokine 10 23.92 Low Low
Inflammatory mediators 14 16.24 Low Low
Paracetamol 2 14.56 Low Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 125 95.48 Very High Very High Very High
Rheumatoid Arthritis 130 91.36 High High
Infection 31 86.88 High High
Cancer 50 84.08 Quite High
Necrosis 14 83.52 Quite High
Synovitis 4 71.52 Quite High
Arthritis 36 67.44 Quite High
Targeted Disruption 25 66.68 Quite High
Pressure And Volume Under Development 4 63.64 Quite High
Disease 49 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once activated, TAK1 activates the IKK complex and eventually activates NF-?
Positive_regulation (activated) of TAK1
1) Confidence 0.24 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.06 Pain Relevance 0
The intracellular signalling cascade of IL-1 is similar to that of the MyD88-dependant TLR cascade discussed previously and involves the induction of IRAK1, IRAK4, MyD88 and transforming growth factor-activated kinase (TAK)1 [26].
Positive_regulation (induction) of TAK
2) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.22 Pain Relevance 0.50
The intracellular signalling cascade of IL-1 is similar to that of the MyD88-dependant TLR cascade discussed previously and involves the induction of IRAK1, IRAK4, MyD88 and transforming growth factor-activated kinase (TAK)1 [26].
Positive_regulation (induction) of transforming growth factor-activated kinase
3) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.21 Pain Relevance 0.50
-activated kinase-1 (TAK1), which phosphorylates IKK?
Positive_regulation (activated) of TAK1
4) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.55 Pain Relevance 0.25

General Comments

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