INT222845

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 27
Total Number 43
Disease Relevance 25.15
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Anatomy Link Frequency
liver 1
hepatocyte 1
MEFs 1
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 296 98.68 Very High Very High Very High
Inflammation 570 95.12 Very High Very High Very High
cINOD 27 91.00 High High
aspirin 1 86.88 High High
Inflammatory response 106 82.08 Quite High
chemokine 120 71.12 Quite High
dexamethasone 3 70.72 Quite High
Bioavailability 4 66.96 Quite High
metalloproteinase 48 57.52 Quite High
Inflammatory mediators 3 46.72 Quite Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 754 100.00 Very High Very High Very High
Hepatotoxicity 17 99.82 Very High Very High Very High
Liver Cancer 48 99.68 Very High Very High Very High
Insulin Resistance 45 99.60 Very High Very High Very High
Cancer 702 98.92 Very High Very High Very High
Death 154 98.68 Very High Very High Very High
Malignant Neoplastic Disease 32 98.60 Very High Very High Very High
Obesity 107 98.56 Very High Very High Very High
Targeted Disruption 215 97.84 Very High Very High Very High
Hepatitis 112 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High expression of IKK?
Gene_expression (expression) of IKK
1) Confidence 0.52 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.70 Pain Relevance 0.22
IKK consists of two catalytic subunits, IKK?
Gene_expression (consists) of IKK
2) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.02 Pain Relevance 0.20
These results suggest that IKK/NF-?
Gene_expression (/) of IKK
3) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.08 Pain Relevance 0.08
Enhanced JNK activation in the absence of IKK?
Neg (absence) Gene_expression (absence) of IKK
4) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.18 Pain Relevance 0.11
IKK consists of two catalytic subunits, IKK?
Gene_expression (consists) of IKK
5) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.03 Pain Relevance 0.20
The roles of IKK?
Gene_expression (roles) of IKK
6) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.64 Pain Relevance 0.17
These results suggest that IKK/NF-?
Spec (suggest) Gene_expression (suggest) of IKK
7) Confidence 0.45 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.09 Pain Relevance 0.08
However, following an injection of concanavalin A (ConA), liver damage becomes worse in IKK?
Gene_expression (worse) of IKK in liver associated with hepatotoxicity
8) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.58 Pain Relevance 0.14
In hepatocyte-specific Ikk?
Gene_expression (specific) of Ikk in hepatocyte
9) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.00 Pain Relevance 0.07
The IKK subunit NEMO/IKK?
Gene_expression (/) of IKK
10) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.27 Pain Relevance 0.08
These effects of IKK?
Gene_expression (effects) of IKK
11) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.19 Pain Relevance 0.07
These results suggest that the negative crosstalk between IKK?
Gene_expression (crosstalk) of IKK
12) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.31 Pain Relevance 0.07
The IKK subunit NEMO/IKK?
Gene_expression (subunit) of IKK
13) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.27 Pain Relevance 0.07
Although IKK?
Gene_expression (Although) of IKK
14) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.63 Pain Relevance 0.20
-deficient mice, and the results showed that JNK1 is a critical factor for the increased incidence of HCC in Ikk?
Gene_expression (incidence) of Ikk associated with hepatocellular cancer
15) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.93 Pain Relevance 0.06
The IKK subunit NEMO/IKK?
Gene_expression (subunit) of IKK
16) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.28 Pain Relevance 0.08
In the absence of IKK?
Neg (absence) Gene_expression (absence) of IKK
17) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.05 Pain Relevance 0
Plasmids expressing IKKs and IKK constitutively active mutants were kindly provided by Dr.
Gene_expression (expressing) of IKK
18) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.26 Pain Relevance 0.06
In keeping with our hypothesis, both pharmacological and dominant negative molecular inhibitions of the IKK?
Gene_expression (hypothesis) of IKK
19) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.15 Pain Relevance 0.03
In the absence of transfected HA-IKK?
Gene_expression (transfected) of IKK
20) Confidence 0.18 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0

General Comments

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