INT222848

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.65
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eefsec) nucleus (Eefsec) translation (Eefsec)
GTPase activity (Eefsec) cytoplasm (Eefsec)
Anatomy Link Frequency
liver 1
Eefsec (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 7 80.12 Quite High
Inflammation 14 50.64 Quite High
Inflammatory mediators 7 31.20 Quite Low
tolerance 28 5.00 Very Low Very Low Very Low
Paracetamol 14 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 7 97.20 Very High Very High Very High
Hepatitis 14 89.12 High High
Fibrosis 7 88.72 High High
Immunodeficiency 7 85.60 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 82.64 Quite High
Acute Liver Failure 29 81.20 Quite High
Cirrhosis 7 80.12 Quite High
Targeted Disruption 21 72.16 Quite High
Cancer 12 63.60 Quite High
Pathologic Neovascularization 2 63.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously utilized SE-1 as a marker of SEC, as SE-1 is reportedly a specific marker of the liver SEC [37].
SEC Binding (marker) of in liver
1) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.52 Pain Relevance 0
Since these enzymes carry terminal mannose they are readily recognized by the SEC MANN-R and internalized.
SEC Binding (recognized) of
2) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0 Pain Relevance 0
SEC can bind but not internalize particles via their endocytosis receptors
SEC Neg (not) Binding (bind) of
3) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.04
Interaction of SEC with virus
SEC Binding (Interaction) of
4) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.45 Pain Relevance 0
That is, if the goal is to target the SEC proper, it will be an easy task to develop a carrier system, since almost any modification of native proteins will make them a ligand for SEC endocytosis receptors.
SEC Binding (ligand) of
5) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0 Pain Relevance 0
Endocytosis receptors in SEC and their macromolecular ligands
SEC Binding (ligands) of
6) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.10 Pain Relevance 0
SEC can bind but not internalize particles via their endocytosis receptors
SEC Neg (not) Binding (bind) of
7) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.04
When dealing with SEC it is obvious that both the COLLA-R, MANN-R, and Fcgamma-R must be regarded as different types of SRs.
SEC Binding (dealing) of
8) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.24 Pain Relevance 0.03
was also investigated by SEC of extracts from wild type, IKK?
SEC Binding (investigated) of
9) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0

General Comments

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