INT222850

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.91
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 107 93.36 High High
aspirin 1 86.88 High High
cytokine 56 69.60 Quite High
chemokine 18 59.64 Quite High
metalloproteinase 9 57.72 Quite High
Inflammatory response 23 32.56 Quite Low
agonist 59 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 141 100.00 Very High Very High Very High
Insulin Resistance 19 99.60 Very High Very High Very High
Death 29 99.40 Very High Very High Very High
Obesity 68 98.56 Very High Very High Very High
Cancer 134 98.12 Very High Very High Very High
INFLAMMATION 133 93.36 High High
Malignant Neoplastic Disease 6 92.88 High High
Liver Cancer 9 90.96 High High
Metabolic Disorder 25 88.36 High High
Apoptosis 43 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced JNK activation in the absence of IKK?
Positive_regulation (activation) of Neg (absence) Gene_expression (absence) of IKK
1) Confidence 0.34 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.19 Pain Relevance 0.11
High expression of IKK?
Positive_regulation (High) of Gene_expression (expression) of IKK
2) Confidence 0.34 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.70 Pain Relevance 0.22
-deficient mice, and the results showed that JNK1 is a critical factor for the increased incidence of HCC in Ikk?
Positive_regulation (increased) of Gene_expression (incidence) of Ikk associated with hepatocellular cancer
3) Confidence 0.29 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.93 Pain Relevance 0.06
To study the effect of B14 on IKK activity further, the IKK complex was activated by overexpression of either IKK?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IKK
4) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.11 Pain Relevance 0
B activation driven by overexpression of either IKK?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IKK
5) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
(Figure 7A) or by expression of the constitutively active IKK?
Positive_regulation (active) of Gene_expression (expression) of IKK
6) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
In the absence of transfected HA-IKK?
Positive_regulation (transfected) of Gene_expression (transfected) of IKK
7) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B activation driven by overexpression of either IKK?
Positive_regulation (activation) of Gene_expression (overexpression) of IKK
8) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
activity or overexpressed IKK promotes insulin resistance, whereas reduction of
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IKK associated with insulin resistance
9) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

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