INT222859

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.33
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (NDUFA6) mitochondrion (NDUFA6) small molecule metabolic process (NDUFA6)
NDUFA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 44 93.76 High High
Inflammation 77 65.08 Quite High
cytokine 55 61.84 Quite High
chemokine 33 49.32 Quite Low
cINOD 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 242 94.28 High High
INFLAMMATION 132 93.40 High High
Sprains And Strains 55 91.44 High High
Cancer 22 88.56 High High
Pox Virus Infection 99 87.28 High High
Death 11 87.28 High High
Apoptosis 22 70.40 Quite High
Necrosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible interaction between B14 and the IKK complex was investigated further by immunoprecipitation.
B14 Binding (interaction) of
1) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.09 Pain Relevance 0
Collectively, these data show that B14, but not N1, associates with the IKK signalosome.
B14 Binding (associates) of
2) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
For instance, the slight increase of PMA-induced AP-1 activity in the presence of B14 (Figure 1D) may result from interaction of B14 with an unidentified protein(s).
B14 Binding (interaction) of
3) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.05 Pain Relevance 0.03
Notably, the interaction between B14 and the IKK complex required IKK?
B14 Binding (interaction) of
4) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233672 Disease Relevance 0.74 Pain Relevance 0.13
The interaction between B14 and IKK?
B14 Binding (interaction) of
5) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Therefore, B14, but not N1, associates with the IKK complex and thereby inhibits NF-?
B14 Binding (associates) of
6) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.07 Pain Relevance 0
B14 functions by interacting with a cellular protein called IKK?
B14 Binding (interacting) of
7) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233672 Disease Relevance 0.86 Pain Relevance 0
B activation, we searched for interactions between B14 and potential ligands using a luminescence-based mammalian interactome mapping (LUMIER) assay [42].
B14 Binding (interactions) of
8) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B14 only co-purified with the IKK complex of 700–900 kDa when IKK?
B14 Binding (purified) of
9) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Data presented show that B14 associates with and inhibits the activity of the IKK complex and thereby inhibits NF-?
B14 Binding (associates) of
10) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.51 Pain Relevance 0.05
is the target for B14.
B14 Binding (target) of
11) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0

General Comments

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