INT222868

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chuk, Pkn1) nucleus (Chuk, Pkn1) kinase activity (Chuk, Pkn1)
endosome (Pkn1) histone binding (Pkn1) intracellular (Pkn1)
Chuk (Mus musculus)
Pkn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 28 41.92 Quite Low
cytokine 20 40.36 Quite Low
Inflammatory response 16 34.00 Quite Low
chemokine 12 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pox Virus Infection 36 50.00 Quite Low
Infection 88 45.40 Quite Low
INFLAMMATION 48 41.92 Quite Low
Sprains And Strains 20 17.44 Low Low
Cancer 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, three independent experiments shown here contradict this: first, N1 did not bind to IKK components in the LUMIER assay (Figure 2B); second, N1 did not co-purify with IKK during biochemical fractionation of infected cells (Figure 2C); and third, N1 did not co-precipitate with IKK components using the anti-NEMO mAb (unpublished data).
IKK Neg (not) Binding (bind) of N1
1) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
However, three independent experiments shown here contradict this: first, N1 did not bind to IKK components in the LUMIER assay (Figure 2B); second, N1 did not co-purify with IKK during biochemical fractionation of infected cells (Figure 2C); and third, N1 did not co-precipitate with IKK components using the anti-NEMO mAb (unpublished data).
IKK Neg (not) Binding (bind) of N1
2) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Collectively, these data show that B14, but not N1, associates with the IKK signalosome.
IKK Binding (associates) of N1
3) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Surprisingly, no interaction between N1 and IKK?
IKK Neg (no) Binding (interaction) of N1
4) Confidence 0.00 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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