INT222876

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 2.02
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) transport (NDUFA6) mitochondrion (NDUFA6)
small molecule metabolic process (NDUFA6) nucleus (Chuk) kinase activity (Chuk)
Anatomy Link Frequency
MEFs 2
NDUFA6 (Homo sapiens)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 64 75.04 Quite High
Inflammation 112 64.28 Quite High
cytokine 80 61.04 Quite High
chemokine 48 5.00 Very Low Very Low Very Low
cINOD 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 352 94.96 High High
Sprains And Strains 80 92.40 High High
Cancer 32 91.36 High High
Death 16 90.08 High High
Pox Virus Infection 144 86.96 High High
INFLAMMATION 192 74.68 Quite High
Apoptosis 32 5.00 Very Low Very Low Very Low
Necrosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify which of the IKK components interacts with B14, mouse embryo fibroblasts (MEFs) lacking IKK?
B14 Binding (interacts) of IKK in MEFs
1) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
In vB14-HA-infected wild type MEFs B14 co-precipitated with the IKK complex (Figure 3A, lane 4).
B14 Binding (precipitated) of IKK in MEFs
2) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
Notably, the interaction between B14 and the IKK complex required IKK?
B14 Binding (complex) of IKK
3) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233672 Disease Relevance 0.74 Pain Relevance 0.13
In contrast, B14 and the IKK complex were not co-immunoprecipitated with a control mAb against glycogen synthase kinase (GSK)-3?
B14 Binding (complex) of IKK
4) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.08 Pain Relevance 0
Furthermore, B14 associated with the IKK complex via IKK?
B14 Binding (associated) of IKK
5) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
The possible interaction between B14 and the IKK complex was investigated further by immunoprecipitation.
B14 Binding (interaction) of IKK
6) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.09 Pain Relevance 0
Collectively, these data show that B14, but not N1, associates with the IKK signalosome.
B14 Binding (associates) of IKK
7) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
These observations indicated that B14 interacts with the IKK complex.
B14 Binding (interacts) of IKK
8) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
These findings indicate that the inhibitory effect of B14 on the activity of the IKK complex is not due to disassembly of the IKK complex.
B14 Binding (complex) of IKK
9) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.05 Pain Relevance 0
B14 co-purified with the IKK complex but was also present in a 160-kDa complex, much larger than the mass of monomeric B14 (17.3 kDa).
B14 Binding (complex) of IKK
10) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Furthermore, B14 associated with the IKK complex via IKK?
B14 Binding (complex) of IKK
11) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Furthermore, B14 associated with the IKK complex via IKK?
B14 Binding (associated) of IKK
12) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B14 functions by interacting with a cellular protein called IKK?
B14 Binding (interacting) of IKK
13) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233672 Disease Relevance 0.88 Pain Relevance 0
is the target of B14 in the complex and B14 did not bind to or disrupt the IKK?
B14 Neg (not) Binding (bind) of IKK
14) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
B14 interacted with IKK?
B14 Binding (interacted) of IKK
15) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Furthermore, B14 associated with the IKK complex via IKK?
B14 Binding (complex) of IKK
16) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0

General Comments

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