INT222877

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.17

plasma membrane (Chrm2, EPHB2) signal transduction (Chrm2) signal transducer activity (Chrm2)

Chrm2 (Mus musculus) EPHB2 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 3 75.20 cytokine 5 74.72 Inflammatory response 4 64.00 Inflammation 7 11.16 cINOD 1 5.00

Disease Link Frequency Relevance Heat Infection 22 99.08 Apoptosis 2 96.28 Pox Virus Infection 9 76.08 INFLAMMATION 12 64.00 Sprains And Strains 5 5.00 Cancer 2 5.00 Death 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lastly, protein M2 downregulates ERK-mediated NF-?

M2 Negative_regulation (downregulates) of ERK

1) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.66 Pain Relevance 0.17

General Comments

This test has worked.