INT222878

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.06
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) transport (NDUFA6) mitochondrion (NDUFA6)
small molecule metabolic process (NDUFA6) nucleus (Chuk) kinase activity (Chuk)
Anatomy Link Frequency
MEFs 1
NDUFA6 (Homo sapiens)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 24 93.76 High High
chemokine 18 49.32 Quite Low
cytokine 30 48.84 Quite Low
Inflammation 42 25.00 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 6 99.92 Very High Very High Very High
Cancer 12 99.32 Very High Very High Very High
Infection 132 99.12 Very High Very High Very High
INFLAMMATION 72 93.40 High High
Pox Virus Infection 54 87.28 High High
Apoptosis 12 70.40 Quite High
Sprains And Strains 30 69.60 Quite High
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify which of the IKK components interacts with B14, mouse embryo fibroblasts (MEFs) lacking IKK?
B14 Negative_regulation (lacking) of IKK in MEFs
1) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
This suggested that B14 reduces IKK activity during VACV infection.
B14 Negative_regulation (reduces) of IKK associated with infection
2) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.53 Pain Relevance 0
Data presented show that B14 associates with and inhibits the activity of the IKK complex and thereby inhibits NF-?
B14 Negative_regulation (inhibits) of IKK
3) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.51 Pain Relevance 0.05
B14 inhibited IKK?
B14 Negative_regulation (inhibited) of IKK
4) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
is the target of B14 in the complex and B14 did not bind to or disrupt the IKK?
B14 Neg (not) Negative_regulation (disrupt) of IKK
5) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
B14 prevents IKK?
B14 Negative_regulation (prevents) of IKK
6) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233672 Disease Relevance 0.90 Pain Relevance 0

General Comments

This test has worked.

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