INT222892

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.78
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA2D2) plasma membrane (CACNA2D2)
Anatomy Link Frequency
neurons 2
CACNA2D2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 4 99.74 Very High Very High Very High
pregabalin 248 99.02 Very High Very High Very High
Calcium channel 6 98.96 Very High Very High Very High
Glutamate receptor 2 98.80 Very High Very High Very High
potassium channel 2 97.84 Very High Very High Very High
sodium channel 2 97.04 Very High Very High Very High
GABA receptor 2 95.24 Very High Very High Very High
gABA 2 93.68 High High
anticonvulsant 4 91.20 High High
Fibrositis 8 90.84 High High
Disease Link Frequency Relevance Heat
Cancer 43 99.12 Very High Very High Very High
Partial Seizures 36 98.78 Very High Very High Very High
Nasopharynx Cancer 103 98.28 Very High Very High Very High
Sleep Disorders 18 90.84 High High
Anxiety Disorder 16 90.56 High High
Post Operative Pain 6 90.12 High High
Diabetic Neuropathy 6 89.16 High High
Convulsion 64 85.96 High High
Pain 15 77.68 Quite High
Epilepsy 58 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
candidate genes such as CACNA2D2, DLC1, FUS1, H37, HYAL1, RASSF1A, SEMA3B, and
CACNA2D2 Binding (genes) of
1) Confidence 0.23 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.08 Pain Relevance 0
Like gabapentin it works by binding to alpha 2 delta subunit of the P/Q-type voltage-sensitive Ca2+ channels (VSCC) which are present in presynaptic neurons.6,7 It does not block calcium channels rather it modulates calcium channels.6 In various animal models pregabalin exhibits anticonvulsant, anxiolytic and analgesic properties.5

Pharmacology

alpha 2 delta subunit Binding (binding) of in neurons associated with pregabalin, analgesic, calcium channel, anxiety disorder, anticonvulsant and gabapentin
2) Confidence 0.06 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732007 Disease Relevance 0.79 Pain Relevance 1.56
Pregabalin in the management of partial epilepsy

Pregabalin is a new antiepileptic medication that works by binding to alpha 2 delta subunit of the voltage-dependent calcium channels present in presynaptic neurons.

alpha 2 delta subunit Binding (binding) of in neurons associated with pregabalin, calcium channel and partial seizures
3) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Title Doc Link PMC2732007 Disease Relevance 0.90 Pain Relevance 0.86

General Comments

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