INT222897

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.44
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
brain 2
SNRNP70 (Homo sapiens)
SNRNP70 - A12P (1)
Pain Link Frequency Relevance Heat
amygdala 9 79.28 Quite High
metalloproteinase 1 67.72 Quite High
drug abuse 8 57.04 Quite High
headache 1 49.72 Quite Low
Migraine 1 49.32 Quite Low
fibrosis 1 46.76 Quite Low
Angina 5 14.64 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 8 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 50 99.64 Very High Very High Very High
Obesity 14 96.76 Very High Very High Very High
Overweight 10 96.16 Very High Very High Very High
Cancer 44 82.88 Quite High
Nasopharynx Cancer 103 82.80 Quite High
Sprains And Strains 1 68.32 Quite High
Disease 32 67.44 Quite High
Diabetes Mellitus 37 57.64 Quite High
Dyslipidemia /

Combined Dyslipidemia

4 57.12 Quite High
Drug Dependence 8 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As brain 5-HT biosynthesis is regulated by TPH2 [6], [26], and TPH2 SNPs increase the risk for psychiatric disorders [27], [28], [29], we decided to further analyze the polymorphic variability of the human TPH2 gene and focused on its coding region.
Regulation (regulated) of Gene_expression (increase) of SNP in brain
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.13 Pain Relevance 0.10
The development of SNP chips [11] has made it possible to genotype SNPs and has
Regulation (development) of Gene_expression (chips) of SNP
2) Confidence 0.34 Published 2008 Journal Bioinformation Section Body Doc Link PMC2533060 Disease Relevance 0.07 Pain Relevance 0
bp from rs2115819, while the ALOX5 SNP rs11239524 is ~11?
Regulation (~11) of Gene_expression (rs11239524) of SNP
3) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
very high density SNP sets in the human genome has been largely centered on the
Regulation (centered) of Gene_expression (sets) of SNP
4) Confidence 0.03 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.35 Pain Relevance 0.03
Pooled estimate of CHD odds ratios were calculated from published studies for the PPARG Ala12Pro SNP including 6898 cases and 11?
Regulation (calculated) of Gene_expression (studies) of SNP (A12P) associated with coronary artery disease
5) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.84 Pain Relevance 0

General Comments

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