INT222905

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2A6) endoplasmic reticulum (CYP2A6) enzyme binding (CYP2A6)
Anatomy Link Frequency
liver 1
CYP2A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 2 72.08 Quite High
Gabapentin 3 71.64 Quite High
carbamazepine 12 70.76 Quite High
Lamotrigine 5 53.68 Quite High
antiepileptic Drug 19 31.08 Quite Low
sodium channel 11 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 22 97.92 Very High Very High Very High
Nasopharynx Cancer 103 96.32 Very High Very High Very High
Nicotine Addiction 2 80.88 Quite High
Cancer 43 58.16 Quite High
Epstein-barr Virus 21 56.08 Quite High
Epilepsy 24 50.00 Quite Low
Convulsion 35 49.72 Quite Low
Body Weight 2 13.28 Low Low
Partial Seizures 14 5.00 Very Low Very Low Very Low
Carcinoma 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
metabolizing genes, such as Cytochrome P450 2A6 (CYP2A6), have also been
Regulation (metabolizing) of CYP2A6
1) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.80 Pain Relevance 0
The activity of CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP3A4, and CYP2C9 was not affected, and only a moderate inhibitory effect on CYP2C19 (by 38%), as well as a moderate increment of UDP-glucuronosyl-transferase 1A1-mediated ethinylestradiol glucuronidation (by 39%), was seen in the presence of ESL in human liver microsomes in vitro.36

In vivo studies

Neg (not) Regulation (affected) of CYP2A6 in liver
2) Confidence 0.12 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0 Pain Relevance 0.17

General Comments

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