INT222906

Context Info Confidence 0.25 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.41 Pain Relevance 0.08

endosome (HLA-DOA) plasma membrane (HLA-DOA)

Anatomy Link Frequency arm 1 T cells 1 HLA-DOA (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 1 93.68 cytokine 7 68.08 cva 6 5.00 spinal inflammation 3 5.00 rheumatoid arthritis 3 5.00 headache 2 5.00 Pain 1 5.00 metalloproteinase 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Adult Respiratory Distress Syndrome 9 99.92 Nasopharynx Cancer 103 99.52 General Immunology 11 98.20 Fever 33 97.36 Disease 69 94.96 Sprains And Strains 38 93.00 Epstein-barr Virus 21 82.48 Organ Transplantation 15 80.28 Carcinoma 13 79.88 Infection 32 74.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Donors who are not perfectly matched with the patients, but homozygous for a given HLA locus can also be used (e.g., patient HLA-A2, 3 and donor HLA-A2 only).

Localization (locus) of HLA

1) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.10 Pain Relevance 0

HLA alloimmunization

Localization (alloimmunization) of HLA

2) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.20 Pain Relevance 0

The HLA System: Genetics, Immunology, Clinical Testing, and Clinical Implications The human major histocompatibility complex HLA is located on the short arm of chromosome 6.

Localization (located) of HLA in arm associated with general immunology

3) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Title Doc Link PMC2628004 Disease Relevance 0.18 Pain Relevance 0

of endemic populations revealed the association of HLA antigen haplotype with

Localization (haplotype) of HLA

4) Confidence 0.06 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.62 Pain Relevance 0.05

To determine whether the remaining 161 peptides were indeed binders to the relevant HLA class I molecules, they were tested in a biochemical in vitro binding assay.

Localization (relevant) of HLA

5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0.03

In the first round of analysis, the 112 peptides identified as binding with a KD of 500 nM or less for the relevant HLA class I molecule, were tested for their ability to stimulate CD8+ T cells from a study population of 11 WNV-infected patients.

Localization (relevant) of HLA in T cells

6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.