INT222919

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.35
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) nucleus (Pde4b) cytoplasm (Pde4b)
Anatomy Link Frequency
nose 2
Pde4b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 98.56 Very High Very High Very High
Inflammation 43 98.44 Very High Very High Very High
Inflammatory response 5 96.32 Very High Very High Very High
rheumatoid arthritis 17 77.84 Quite High
Arthritis 10 66.72 Quite High
chemokine 4 51.28 Quite High
Inflammatory mediators 1 29.00 Quite Low
Leflunomide 8 6.16 Low Low
methotrexate 9 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 46 98.44 Very High Very High Very High
Pulmonary Disease 20 97.00 Very High Very High Very High
Pneumonia 7 94.36 High High
Granuloma 30 93.08 High High
Targeted Disruption 6 80.56 Quite High
Hypersensitivity 7 79.28 Quite High
Rheumatoid Arthritis 17 77.84 Quite High
Increased Venous Pressure Under Development 3 69.80 Quite High
Pressure And Volume Under Development 1 68.48 Quite High
Experimental Arthritis 1 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used a nose-only sub-acute smoke model to assess the effect of local inhibition of PDE4B, PDE4D and PDE7A mRNA on neutrophilic inflammation.
Regulation (effect) of Negative_regulation (inhibition) of PDE4B in nose associated with inflammation
1) Confidence 0.41 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.68 Pain Relevance 0.24
Phosphodiesterase 4 (PDE4) inhibitors are key
Regulation (key) of Negative_regulation (inhibitors) of Phosphodiesterase 4
2) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 1.68 Pain Relevance 0.42

General Comments

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