INT222922

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 17 99.72 Very High Very High Very High
cytokine 38 96.60 Very High Very High Very High
Leflunomide 8 88.88 High High
Inflammation 12 75.00 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 17 99.72 Very High Very High Very High
Granuloma 30 97.64 Very High Very High Very High
INFLAMMATION 13 75.00 Quite High
Arthritis 9 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Asthma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both PDE4 inhibitors, KF66490 and SB207499, suppressed the production of IL-1?
Negative_regulation (inhibitors) of PDE4 Negative_regulation (suppressed) of Gene_expression (production) of IL-1
1) Confidence 0.01 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC2233982 Disease Relevance 0.56 Pain Relevance 0.44

General Comments

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