INT222923

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) signal transduction (Pde4a)
oxidoreductase activity (Mpo) nucleus (Pde4a) lysosome (Mpo)
Pde4a (Mus musculus)
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Leflunomide 8 99.96 Very High Very High Very High
rheumatoid arthritis 17 90.76 High High
cytokine 38 87.64 High High
Inflammation 12 75.00 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 17 90.76 High High
Granuloma 30 88.68 High High
INFLAMMATION 13 75.00 Quite High
Arthritis 9 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Asthma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to leflunomide, PDE4 inhibitors more strongly suppressed IL-12 production and the increase in myeloperoxidase activity.
Negative_regulation (inhibitors) of PDE4 Negative_regulation (suppressed) of Positive_regulation (increase) of myeloperoxidase associated with leflunomide
1) Confidence 0.04 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC2233982 Disease Relevance 0.59 Pain Relevance 0.45

General Comments

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