INT222968

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 1.10
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neurons 10
sympathetic 2
nucleus ambiguus 2
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 173 87.76 High High
withdrawal 36 86.72 High High
medulla 8 84.64 Quite High
Nerve growth factor 116 83.68 Quite High
addiction 8 81.60 Quite High
Dorsal horn 18 79.40 Quite High
noradrenaline 26 70.48 Quite High
Spinal cord 41 61.92 Quite High
Neuropeptide 28 54.56 Quite High
spinal dorsal horn 16 51.08 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 68 100.00 Very High Very High Very High
Nociception 43 100.00 Very High Very High Very High
Ganglion Cysts 326 99.62 Very High Very High Very High
Low Back Pain 14 50.00 Quite Low
Apoptosis 32 47.32 Quite Low
Death 29 15.44 Low Low
Hyperalgesia 8 7.28 Low Low
Ocular Toxicity (including Many Sub-types) 24 5.76 Low Low
INFLAMMATION 8 5.12 Low Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prominent difference between ChAT+ and ChAT?
Negative_regulation (difference) of Gene_expression (prominent) of ChAT
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Reduced nociceptive thresholds by ChAT-knock down
Negative_regulation (Reduced) of Gene_expression (thresholds) of ChAT associated with targeted disruption and nociception
2) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.40 Pain Relevance 0.26
Reduced nociceptive thresholds by ChAT-knock down
Negative_regulation (knock) of Gene_expression (thresholds) of ChAT associated with targeted disruption and nociception
3) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.35 Pain Relevance 0.23
Of 50 recordings (from 29 mice) we identified 9 ChAT+ neurons and 30 ChAT?
Negative_regulation (identified) of Gene_expression (neurons) of ChAT in neurons
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
The difference in spike rate was sufficiently pronounced that the neurons could readily be identified as ChAT+ or ChAT?
Negative_regulation (pronounced) of Gene_expression (identified) of ChAT in neurons
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.13
The difference in spike rate was sufficiently pronounced that the neurons could readily be identified as ChAT+ or ChAT?
Negative_regulation (pronounced) of Gene_expression (identified) of ChAT in neurons
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.12
A prominent difference between ChAT+ and ChAT?
Negative_regulation (difference) of Gene_expression (prominent) of ChAT
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Of 50 recordings (from 29 mice) we identified 9 ChAT+ neurons and 30 ChAT?
Negative_regulation (identified) of Gene_expression (neurons) of ChAT in neurons
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
No glycinergic neurons are found in the pars compacta of the nucleus ambiguus. f Overlay of d and e reveals no EGFP expression in ChAT-positive neurons.
Negative_regulation (reveals) of Neg (no) Gene_expression (expression) of ChAT in nucleus ambiguus
9) Confidence 0.26 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691554 Disease Relevance 0 Pain Relevance 0.11
An essential aspect of this process is the loss of ChAT and VAChT expression in a large number of sympathetic neurons (Burau et al. 2004).
Negative_regulation (loss) of Gene_expression (expression) of ChAT in neurons
10) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.10
After embryonic day 14, most cells lose ChAT and VAChT expression.
Negative_regulation (lose) of Gene_expression (expression) of ChAT
11) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.12
The number of STG cells with strong expression of ChAT and VAChT mRNAs is reduced in mutant animals by more than 80%.
Negative_regulation (reduced) of Gene_expression (expression) of ChAT associated with ganglion cysts
12) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.28 Pain Relevance 0.03
This has been confirmed in newborn ret mutant mice, which almost entirely lose the expression of ChAT and VAChT mRNAs in sympathetic ganglia.
Negative_regulation (lose) of Gene_expression (expression) of ChAT in sympathetic
13) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0

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