INT222970

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.96
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
cholinergic neurons 1
neurons 1
central nervous system 1
dorsal horn 1
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 6 99.44 Very High Very High Very High
Dorsal horn 9 99.24 Very High Very High Very High
gABA 53 96.96 Very High Very High Very High
Spinal cord 48 96.88 Very High Very High Very High
Pain 15 96.40 Very High Very High Very High
GABAergic 18 95.72 Very High Very High Very High
dorsal root ganglion 31 94.44 High High
Neuropathic pain 9 94.36 High High
agonist 12 93.56 High High
Nerve growth factor 1 93.12 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 43 98.50 Very High Very High Very High
Pain 9 96.40 Very High Very High Very High
Neuropathic Pain 9 94.36 High High
Ganglion Cysts 57 93.96 High High
Nervous System Injury 2 87.68 High High
Low Back Pain 7 75.00 Quite High
Nociception 19 70.16 Quite High
Disease 7 50.00 Quite Low
Umbilical Hernia 24 40.56 Quite Low
Alzheimer's Dementia 7 40.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To immunostain MNs and other cholinergic neurons we used a goat polyclonal antibody specifically directed against choline acetyltransferase (ChAT; 1?
Localization (directed) of choline acetyltransferase in cholinergic neurons
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909228 Disease Relevance 0 Pain Relevance 0.08
ChAT+ neurons fire at lower frequencies than ChAT?
Localization (fire) of ChAT in neurons
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Here, we show that choline acetyltransferase (ChAT) signals were localized not only in outer dorsal horn fibers (lamina I–III) and motor neurons in the spinal cord, but also in the vast majority of neurons in the dorsal root ganglion (DRG).
Localization (localized) of ChAT in dorsal horn associated with ganglion cysts, dorsal root ganglion, dorsal horn and spinal cord
3) Confidence 0.61 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2234393 Disease Relevance 0.69 Pain Relevance 0.76
In VAChT knockout mice the amount of the ACh-synthesizing enzyme choline acetyltransferase (ChAT) is increased at the mRNA and protein levels compared to their wild-type littermates, suggesting that the change in ChAT expression may be related to a compensatory mechanism due to the lack of ACh release [16].
Neg (lack) Localization (release) of ChAT associated with targeted disruption
4) Confidence 0.52 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.28 Pain Relevance 0.61
There was a reduction in the relative abundance of ChAT/CRABP-positive cells by about 23% with atropine treatment (n = 6, p = 0.021) or by about 38% with carbachol treatment (n = 4, p = 0.018) (Fig. 6g).
Localization (abundance) of ChAT
5) Confidence 0.21 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0.07
Consistent with these reports, Chol-1 antigens were found to co-localize with choline acetyltransferase in the human central nervous system (Whittaker et al., 1992).
Localization (localize) of choline acetyltransferase in central nervous system associated with central nervous system
6) Confidence 0.15 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0 Pain Relevance 0.14

General Comments

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