INT222971

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
afferent neurons 4
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 18 99.62 Very High Very High Very High
Spinal cord 24 94.40 High High
Pain 28 93.44 High High
dorsal root ganglion 62 93.12 High High
spinal dorsal horn 16 68.36 Quite High
Dorsal horn 18 64.08 Quite High
GABAergic 6 61.48 Quite High
agonist 14 60.28 Quite High
Neuropathic pain 18 52.72 Quite High
intrathecal 12 40.76 Quite Low
Disease Link Frequency Relevance Heat
Low Back Pain 14 93.44 High High
Ganglion Cysts 62 93.12 High High
Injury 2 83.40 Quite High
Neuropathic Pain 18 52.72 Quite High
Nociception 38 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we attempted to clarify the role of primary afferent neurons in this tonic inhibition and to reproduce nicotinic analgesia with low doses by down-regulation of ChAT activity, based on this speculation.


Negative_regulation (down) of Negative_regulation (regulation) of ChAT in afferent neurons associated with analgesia
1) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.63 Pain Relevance 0.76
In the present study we attempted to clarify the role of primary afferent neurons in this tonic inhibition and to reproduce nicotinic analgesia with low doses by down-regulation of ChAT activity, based on this speculation.


Negative_regulation (regulation) of Negative_regulation (down) of ChAT in afferent neurons associated with analgesia
2) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.63 Pain Relevance 0.76

General Comments

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