INT222987

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL1A1, MMP1) peptidase activity (MMP1) extracellular space (COL1A1)
proteinaceous extracellular matrix (MMP1) cytoplasm (COL1A1)
Anatomy Link Frequency
endothelial cells 3
COL1A1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 61.36 Quite High
Inflammation 19 50.00 Quite Low
fibrosis 8 50.00 Quite Low
Inflammatory marker 1 49.72 Quite Low
chemokine 5 46.84 Quite Low
Pain 2 38.48 Quite Low
Chronic pancreatitis 33 36.52 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 77 97.08 Very High Very High Very High
Disease 2 53.80 Quite High
Fibrosis 21 53.44 Quite High
INFLAMMATION 20 50.00 Quite Low
Complex Regional Pain Syndromes 2 38.84 Quite Low
Pancreatitis 33 36.52 Quite Low
Apoptosis 2 25.60 Quite Low
Cirrhosis 7 11.28 Low Low
Sepsis 15 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this site specific variance in ECM deposition can be due to the following reasons: 1) The packed immune clusters are actually forming in expanded perivascular spaces as hinted by the presence of central CD31 positive endothelial cells; 2) In vitro, the matrix degradation enzyme MMP-1 was increased together with an increase in ECM proteins collagen1 and fibronectin; 3) High amounts of TNFalpha exert cytotoxic effects on PSC [20] which is probably represented in vivo as a function of their density.
Positive_regulation (increase) of collagen1 in endothelial cells Positive_regulation (increased) of Protein_catabolism (degradation) of MMP-1 in endothelial cells associated with primary sclerosing cholangitis
1) Confidence 0.01 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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