INT222991

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 4.39
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
chondrocytes 2
lung 2
articular cartilage 2
neural 2
mononuclear cell 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 98.56 Very High Very High Very High
cytokine 96 98.28 Very High Very High Very High
Peripheral nervous system 1 95.28 Very High Very High Very High
Central nervous system 7 93.88 High High
COX2 52 80.48 Quite High
metalloproteinase 8 79.92 Quite High
Inflammation 45 78.16 Quite High
Infliximab 40 57.88 Quite High
fibrosis 16 50.00 Quite Low
Osteoarthritis 31 41.68 Quite Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 240 100.00 Very High Very High Very High
Pancreatitis 33 98.56 Very High Very High Very High
Cirrhosis 17 96.08 Very High Very High Very High
Primary Sclerosing Cholangitis 77 94.00 High High
Apoptosis 16 92.68 High High
Osteoarthritis 32 83.88 Quite High
Rheumatoid Arthritis 49 80.00 Quite High
INFLAMMATION 47 78.16 Quite High
Adhesions 10 77.60 Quite High
Stress 34 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of ECM production in mononuclear cell infiltrates in chronic pancreatitis
Negative_regulation (Suppression) of Gene_expression (production) of ECM in mononuclear cell associated with chronic pancreatitis
1) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.40 Pain Relevance 0.27
-SMA as well as by the decrease of ECM protein expression.
Negative_regulation (decrease) of Gene_expression (expression) of ECM protein
2) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.23 Pain Relevance 0.25
Our results demonstrated that a rise in ATRA exposure impacted leiomyoma cell proliferation and altered ECM production.
Negative_regulation (altered) of Gene_expression (production) of ECM associated with uterine fibroids
3) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.08 Pain Relevance 0.08
8m) inhibited growth of leiomyoma cells in culture and regulated expression of leiomyoma cell ECM structural components, proteoglycans, and cytokines to levels that approximated expression patterns of myometrial cells.
Negative_regulation (inhibited) of Gene_expression (expression) of ECM associated with uterine fibroids and cytokine
4) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.31 Pain Relevance 0.09
According to a previous study on rat lung fibroblasts [30], we found that the functional inhibition of ECM contraction by human joint capsule MFs upon TNF-?
Negative_regulation (inhibition) of Gene_expression (contraction) of ECM in lung
5) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.14 Pain Relevance 0.12
Abundant ECM is present at the time when neural progenitors differentiate, migrate and neuronal axons elongate, but expression of ECM proteins is substantially reduced by the end of development [9,10].
Negative_regulation (reduced) of Gene_expression (expression) of ECM in neural
6) Confidence 0.06 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.08 Pain Relevance 0.19
The marked GS-mediated increase of these proteins in chondrocytes points to an elevation in ECM protein synthesis, which might be also hypothesized by the detected increase in Type IV Collagen (COL6A1, essential for chondrocyte anchoring to the pericellular matrix [49]) synthesis caused by GS.
Negative_regulation (elevation) of Gene_expression (synthesis) of ECM protein in chondrocytes
7) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.26 Pain Relevance 0.06
Collagen sponges supported the most abundant ECM formation, whether the ECM production was nearly absent in fibrin gel.
Spec (whether) Negative_regulation (absent) of Neg (absent) Spec (whether) Gene_expression (production) of ECM
8) Confidence 0.04 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0
Gruber et al. assessed the ECM expression of AF cells in different 3D culture environments including collagen sponge, collagen gel, agarose, alginate and fibrin [39].
Negative_regulation (assessed) of Gene_expression (expression) of ECM
9) Confidence 0.03 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0
Collagen sponges supported the most abundant ECM formation, whether the ECM production was nearly absent in fibrin gel.
Spec (whether) Negative_regulation (supported) of Spec (whether) Gene_expression (formation) of ECM
10) Confidence 0.03 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0
Yamazaki showed that gene expression in AF cells for key ECM components such as aggrecan and type II collagen was suppressed following vibratory loading [126].
Negative_regulation (suppressed) of Gene_expression (expression) of ECM
11) Confidence 0.03 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.72 Pain Relevance 0.08
Taken together, treatment of disc cells with FGF2 increases cell proliferation and decreases ECM production, resulting in clusters of disc cells in a fibrocartilage network similar to our findings from human articular cartilage [15].
Negative_regulation (decreases) of Gene_expression (production) of ECM in articular cartilage
12) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0.16 Pain Relevance 0

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