INT22301

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Context Info
Confidence 0.63
First Reported 1987
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 66
Total Number 72
Disease Relevance 59.49
Pain Relevance 14.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
macrophage 12
CSF 12
blood 8
neutrophil 7
anterior region 6
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 636 100.00 Very High Very High Very High
cytokine 429 100.00 Very High Very High Very High
intrathecal 232 100.00 Very High Very High Very High
metalloproteinase 117 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
fibrosis 9 99.92 Very High Very High Very High
Multiple sclerosis 270 99.78 Very High Very High Very High
Lasting pain 8 99.68 Very High Very High Very High
Central nervous system 303 99.16 Very High Very High Very High
reflex sympathetic dystrophy 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 850 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 722 100.00 Very High Very High Very High
INFLAMMATION 708 100.00 Very High Very High Very High
Asthma 167 100.00 Very High Very High Very High
Adhesions 50 100.00 Very High Very High Very High
Transitional Cell Carcinoma 1 100.00 Very High Very High Very High
Choroid Plexus Papilloma 2 99.98 Very High Very High Very High
Fibrosis 13 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 157 99.88 Very High Very High Very High
Leukocytosis 187 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05).
Positive_regulation (increased) of Gene_expression (levels) of CSF in CSF associated with pain and lasting pain
1) Confidence 0.63 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20211694 Disease Relevance 0.74 Pain Relevance 0.64
The cystatin C increase also was detectable by SELDI with either raw CSF or after antibody capture.
Positive_regulation (increase) of Gene_expression (detectable) of CSF in CSF
2) Confidence 0.50 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.65 Pain Relevance 0.69
CSF infection is importantly influenced by the CSF WBC response, the degree of systemic immunological progression as measured by blood CD4+ T cells, antiretroviral treatment and drug resistance, and the presence of active ADC.
Positive_regulation (measured) of Gene_expression (presence) of CSF in T cells associated with infection
3) Confidence 0.49 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.08 Pain Relevance 0
Probably the only true non-obstructive types of hydrocephalus are venous sinus thrombosis, and choroid plexus papilloma leading to CSF overproduction.
Positive_regulation (leading) of Gene_expression (overproduction) of CSF in choroid plexus associated with intracranial sinus thrombosis, choroid plexus papilloma and hydrocephalus
4) Confidence 0.45 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.46 Pain Relevance 0.14
G-CSF produced a rapid increase of neutrophil levels, was well-tolerated, and was associated with only one frequent adverse effect: bone pain.
Positive_regulation (increase) of Gene_expression (produced) of G-CSF in neutrophil associated with pain
5) Confidence 0.44 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.43 Pain Relevance 0.16
Placental and blood-CSF transfer of intramuscularly administered atropine in the same person.
Positive_regulation (transfer) of Gene_expression (transfer) of CSF in blood
6) Confidence 0.44 Published 1987 Journal Pharmacol. Toxicol. Section Title Doc Link 3575243 Disease Relevance 0 Pain Relevance 0.09
All 39 children received of either G-CSF or GM-CSF (5 micrograms/kg/day) subcutaneously at the end of each chemotherapy course for a maximum duration of 14 days.
Positive_regulation (received) of Gene_expression (received) of GM-CSF
7) Confidence 0.44 Published 1995 Journal Pediatr Hematol Oncol Section Abstract Doc Link 8589000 Disease Relevance 0.47 Pain Relevance 0
All 39 children received of either G-CSF or GM-CSF (5 micrograms/kg/day) subcutaneously at the end of each chemotherapy course for a maximum duration of 14 days.
Positive_regulation (received) of Gene_expression (received) of G-CSF
8) Confidence 0.44 Published 1995 Journal Pediatr Hematol Oncol Section Abstract Doc Link 8589000 Disease Relevance 0.47 Pain Relevance 0
In a longer term study, five patients received GM-CSF for two to nine weeks, although only one maintained increased neutrophil counts, one developed antibodies to GM-CSF and one's condition evolved into AML.
Positive_regulation (received) of Gene_expression (received) of GM-CSF in neutrophil associated with myeloid leukemia
9) Confidence 0.44 Published 1990 Journal Cancer Surv. Section Abstract Doc Link 2276114 Disease Relevance 0.50 Pain Relevance 0
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig. 3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (illustrated) of Gene_expression (motion) of CSF in anterior region
10) Confidence 0.44 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0
Local concentrations and the range of distribution in the oscillating CSF for different types of injection were characterized quantitatively in this manner.Fig. 4Simulation of an intrathecal injection (flow rate: 0.3 ml/s) at lumbar site L2 based on an oscillating CSF flow (a) 1 s and (b) 3 s after the start of the injection
Positive_regulation (oscillating) of Gene_expression (oscillating) of CSF associated with intrathecal
11) Confidence 0.44 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.21
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig. 3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (3Simulation) of Gene_expression (motion) of CSF in anterior region
12) Confidence 0.44 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0
Local concentrations and the range of distribution in the oscillating CSF for different types of injection were characterized quantitatively in this manner.Fig. 4Simulation of an intrathecal injection (flow rate: 0.3 ml/s) at lumbar site L2 based on an oscillating CSF flow (a) 1 s and (b) 3 s after the start of the injection
Positive_regulation (oscillating) of Gene_expression (flow) of CSF associated with intrathecal
13) Confidence 0.44 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.20
Local concentrations and the range of distribution in the oscillating CSF for different types of injection were characterized quantitatively in this manner.Fig. 4Simulation of an intrathecal injection (flow rate: 0.3 ml/s) at lumbar site L2 based on an oscillating CSF flow (a) 1 s and (b) 3 s after the start of the injection
Positive_regulation (oscillating) of Gene_expression (flow) of CSF associated with intrathecal
14) Confidence 0.44 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.21
Tachibana et al., showed that G-CSF production by transitional cell carcinoma of the bladder augments autocrine growth, which may in part explain the poor prognoses [14].
Positive_regulation (augments) of Gene_expression (production) of G-CSF in bladder associated with transitional cell carcinoma
15) Confidence 0.44 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.06 Pain Relevance 0
Lumbar puncture identified low CSF pressure and intrathecal gadolinium enhanced MR cisternography showed diffuse CSF leakage in the thoracolumbar region.
Positive_regulation (enhanced) of Gene_expression (pressure) of CSF in CSF associated with lumbar puncture related headaches and intrathecal
16) Confidence 0.43 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20036551 Disease Relevance 1.31 Pain Relevance 0.36
When followed in clinic he showed a low white cell count with an absolute neutrophil count (ANC) of200 cells/microL on day 11 after cycle 2 despite being on G-CSF 300 ?
Positive_regulation (on) of Gene_expression (being) of G-CSF in neutrophil
17) Confidence 0.43 Published 2008 Journal Cases J Section Body Doc Link PMC2615768 Disease Relevance 0.90 Pain Relevance 0.16
It is also possible that the function of G-CSF production was acquired as a result of genetic alteration during the course of tumor development in the current case.


Positive_regulation (acquired) of Gene_expression (production) of G-CSF associated with cancer
18) Confidence 0.43 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.39 Pain Relevance 0
Namely, CSF infection showed a proportionally greater response to treatment than plasma infection in the face of antiviral drug resistance.
Positive_regulation (response) of Gene_expression (infection) of CSF in face associated with infection
19) Confidence 0.42 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.76 Pain Relevance 0.04
How do systemic infection and its progressive damage to the immune system affect the VL in a non-lymphatic compartment like the CSF space?
Positive_regulation (compartment) of Gene_expression (space) of CSF in immune system associated with infection
20) Confidence 0.42 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.33 Pain Relevance 0.04

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