INT223021

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.76
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Psc) DNA binding (Psc)
Anatomy Mention Frequency
PSC 2
Psc (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
Cannabinoid receptor 18 99.78 Very High Very High Very High
Chronic pancreatitis 64 99.32 Very High Very High Very High
Cannabinoid 26 94.16 High High
Endocannabinoid 24 91.84 High High
Inflammation 32 89.32 High High
cytokine 31 83.76 Quite High
antagonist 23 81.44 Quite High
fibrosis 20 75.00 Quite High
agonist 6 54.72 Quite High
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Primary Sclerosing Cholangitis 121 100.00 Very High Very High Very High
Pancreatitis 65 99.32 Very High Very High Very High
Sepsis 15 99.04 Very High Very High Very High
INFLAMMATION 34 89.32 High High
Fibrosis 32 75.00 Quite High
Cirrhosis 22 72.24 Quite High
Stress 2 65.44 Quite High
Apoptosis 13 57.76 Quite High
Neurosyphilis 1 50.24 Quite High
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Particularly, while there was a tendency towards an increase in fibronectin production following PSC co-culture with CP and septic shock PBMC, this increase could also have been due to activation of PSC under culture conditions (plastic cell culture dishes which lead to activation of PSC).
Positive_regulation (increase) of Positive_regulation (following) of PSC associated with primary sclerosing cholangitis, chronic pancreatitis and sepsis
1) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.56 Pain Relevance 0.44
Activation of cannabinoid receptors, however, induced de-activation of PSC and dose-dependently inhibited growth and decreased IL-6 and MCP-1 secretion as well as fibronectin, collagen1 and alphaSMA levels.
Positive_regulation (induced) of Positive_regulation (activation) of PSC in PSC associated with cannabinoid receptor and primary sclerosing cholangitis
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2253501 Disease Relevance 1.20 Pain Relevance 1.03

General Comments

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