INT223026

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.38
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
plaques 1
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 4 81.92 Quite High
Arthritis 3 81.28 Quite High
ischemia 4 71.40 Quite High
Inflammation 5 59.20 Quite High
fibrosis 2 46.56 Quite Low
Dopamine 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 24 97.62 Very High Very High Very High
Hypoxia 6 95.88 Very High Very High Very High
Disease 18 95.52 Very High Very High Very High
Cancer 25 94.60 High High
Atherosclerotic Plaque 2 93.64 High High
Injury 3 88.44 High High
Metabolic Syndrome 2 87.28 High High
Syndrome 33 86.12 High High
Kidney Stones 3 83.12 Quite High
Crystal Associated Disease 12 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore XO production may not necessarily be reflected by systemic levels of XO metabolites.41

The XO inhibitor allopurinol

Neg (not) Spec (may) Regulation (reflected) of XO
1) Confidence 0.32 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.69 Pain Relevance 0
Despite this, the activity of endothelial bound XO is increased by more than 200% in patients with CHF.36 Furthermore, studies using electron spin resonance have demonstrated that endothelial oxygen tension is thought to regulate XO activity at a post-translational level as demonstrated by a doubling in XOR activity post exposure to hypoxia without any increase in mRNA expression for 24 hours in bovine aortic endothelial cells.37 Cells produce a marked elevation in XO levels when exposed to ischemia38 and XDH conversion to XO is also accelerated in hypoxia.39 When infused acutely, XO produces a marked decrease in cardiac contractility, cardiac index and left ventricular systolic pressure.40 In atherosclerotic plaques, urate levels are found to be elevated six-fold, reflecting accelerated purine oxidation within these plaques.
Spec (found) Regulation (regulate) of XO in plaques associated with atherosclerotic plaque, hypoxia and myocardial infarction
2) Confidence 0.22 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.81 Pain Relevance 0.04
Allopurinol is rapidly metabolized by its target, xanthine oxidase, to its active metabolite oxypurinol, which is also an inhibitor of xanthine oxidase.
Regulation (target) of xanthine oxidase
3) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.48 Pain Relevance 0.04
Uric acid overproduction can be controlled with the xanthine oxidase inhibitor allopurinol that blocks the conversion of xanthine and hypoxanthine into uric acid [78].
Regulation (controlled) of xanthine oxidase
4) Confidence 0.03 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.41 Pain Relevance 0.07

General Comments

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