INT223078

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.64
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
vasculature 2
mesenchymal cells 2
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 101 99.44 Very High Very High Very High
Arthritis 1 53.84 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 234 99.60 Very High Very High Very High
Pulmonary Fibrosis 68 99.44 Very High Very High Very High
Experimental Melanoma 7 94.64 High High
Solid Tumor 2 92.80 High High
Gastrointestinal Stromal Tumor 135 84.68 Quite High
Disease 41 80.80 Quite High
Fibrosis 58 72.12 Quite High
Targeted Disruption 14 67.24 Quite High
Hyperplasia 3 64.80 Quite High
Apoptosis 44 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-?
Negative_regulation (where) of Gene_expression (produced) of PDGFR in vasculature
1) Confidence 0.35 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.63 Pain Relevance 0
Agents that downregulate PDGFR expression at the cell surface of mesenchymal cells could also be of potential therapeutic value.
Negative_regulation (downregulate) of Gene_expression (expression) of PDGFR in mesenchymal cells
2) Confidence 0.29 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.94 Pain Relevance 0.25
Moreover, tumor shrinkage could be observed even in cases with less favorable KIT/PDGFR?
Negative_regulation (less) of Gene_expression (favorable) of PDGFR associated with cancer
3) Confidence 0.17 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.00 Pain Relevance 0
Moreover, tumor shrinkage could be observed even in cases with less favorable KIT/PDGFR?
Negative_regulation (even) of Gene_expression (observed) of PDGFR associated with cancer
4) Confidence 0.17 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.06 Pain Relevance 0

General Comments

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