INT223080

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 7.21
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
platelet 3
mesenchymal cell 2
bone marrow 1
dorsal horn 1
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 406 99.44 Very High Very High Very High
Dorsal horn 57 98.52 Very High Very High Very High
lidocaine 3 96.52 Very High Very High Very High
Inflammation 83 96.32 Very High Very High Very High
intrathecal 42 95.40 Very High Very High Very High
chemokine 30 91.76 High High
Brush evoked pain 60 89.60 High High
anesthesia 8 84.20 Quite High
isoflurane 11 83.76 Quite High
withdrawal 21 83.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 31 99.54 Very High Very High Very High
Cancer 223 99.52 Very High Very High Very High
Pulmonary Fibrosis 272 99.44 Very High Very High Very High
Myelofibrosis 28 99.42 Very High Very High Very High
Paralysis 6 98.44 Very High Very High Very High
Fibrosis 235 97.92 Very High Very High Very High
Experimental Melanoma 14 96.92 Very High Very High Very High
Hyperplasia 4 96.64 Very High Very High Very High
INFLAMMATION 106 96.32 Very High Very High Very High
Leukemia 6 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B) complex, platelet-derived growth factor BB (PDGF BB), p38 mitogen- activated protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) complex.
platelet-derived growth factor BB Binding (complex) of in platelet
1) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.39 Pain Relevance 0.13
Recently, PDGF receptor signaling was shown to be perturbed by mutations within the activation loop of PDGFR-?
PDGF Binding (receptor) of
2) Confidence 0.17 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.73 Pain Relevance 0.03
Platelet-derived growth factor receptor-?
Platelet-derived growth factor Binding (receptor) of in Platelet
3) Confidence 0.17 Published 2007 Journal BMC Cancer Section Title Doc Link PMC2234427 Disease Relevance 0.81 Pain Relevance 0
Although polypeptide growth factors such as PDGF and EGF ligands are important for maintaining mesenchymal cell survival and proliferation, the survival of these cells is also determined in large part by the type of inflammatory microenvironment.
PDGF Binding (ligands) of in mesenchymal cell associated with inflammation
4) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.94 Pain Relevance 0.32
First, PDGF ligands are elevated in patients with idiopathic pulmonary fibrosis, and immunohistochemical studies have shown that increased expression of PDGFs occurs at sites of fibroproliferative lesions [28].
PDGF Binding (ligands) of associated with fibrosis and pulmonary fibrosis
5) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.53 Pain Relevance 0.14
Collectively, these transgenic studies indicate that PDGF and its receptors are critical to lung mesenchymal cell survival during pulmonary fibrogenesis.
PDGF Binding (critical) of in mesenchymal cell associated with fibrosis and targeted disruption
6) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.91 Pain Relevance 0.07
, whereas PDGF-BB, -AB, and -DD isoforms bind both PDGF-R?
PDGF Binding (bind) of
7) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.37 Pain Relevance 0.10
The employment of imatinib for the therapy of patients with PMF was based on its inhibitory activity against PDGF-mediated signaling and the reduction of bone marrow fibrosis and microvessel density observed in patients with chronic myeloid leukemia (CML), for which imatinib is a standard therapy (Kvasnicka and Thiele 2004).
PDGF Binding (activity) of in bone marrow associated with fibrosis, leukemia, myeloid leukemia and myelofibrosis
8) Confidence 0.06 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.46 Pain Relevance 0.05
phosphorylation in the dorsal horn (Figure 3F), indicating that minocycline does not directly interrupt the PDGF binding to the PDGFR?
PDGF Binding (binding) of in dorsal horn associated with dorsal horn
9) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.35 Pain Relevance 0.57
PDGF-AA, -BB, -AB, and -CC bind to PDGFR?
PDGF Binding (bind) of
10) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.51 Pain Relevance 0.68
A recombinant human platelet-derived growth factor, PDGF-BB (0.1, 1 and 10 pmol/10 ?
PDGF Binding (recombinant) of in platelet
11) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.19 Pain Relevance 0.36

General Comments

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