INT223134

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.94
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cib1) endoplasmic reticulum (Cib1) plasma membrane (Cib1)
nucleus (Cib1) cytoplasm (Cib1)
Anatomy Link Frequency
neurons 2
DRG 1
Cib1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 584 99.38 Very High Very High Very High
dorsal root ganglion 232 99.28 Very High Very High Very High
agonist 36 99.04 Very High Very High Very High
qutenza 12 98.04 Very High Very High Very High
cOX1 8 91.00 High High
Kinase C 84 90.32 High High
bradykinin 12 85.96 High High
Hyperalgesia 4 84.72 Quite High
Inflammation 8 81.80 Quite High
Thermal hyperalgesia 8 76.20 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 236 99.28 Very High Very High Very High
Hyperalgesia 12 84.72 Quite High
INFLAMMATION 12 81.80 Quite High
Neuropathic Pain 4 68.96 Quite High
Nociception 12 51.20 Quite High
Inflammatory Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the neurokinin-1 receptor activation by its agonists regulates the SP release process involving the activation of MAP kinases, PKCs and COX-2 from cultured DRG neurons.



Positive_regulation (activation) of PKCs in DRG associated with dorsal root ganglion, agonist and substance p
1) Confidence 0.02 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2235838 Disease Relevance 0.36 Pain Relevance 0.72
Whether the complex process of SP release induced by GR73632 requires the activation of MAP kinases, COXs, PLC or PKCs, PKA in cultured DRG neurons, still remains to be elucidated.
Positive_regulation (activation) of PKCs in neurons associated with dorsal root ganglion and substance p
2) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.48 Pain Relevance 0.64
Moreover, the de novo protein synthesis of COX-2 requires the activation of PKCs and MEK (Fig. 6B).
Positive_regulation (activation) of PKCs
3) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.68 Pain Relevance 0.94
Similar to the observation reported by Zhang et al. [38], we also observed that the activation of neurokinin-1 receptor by its agonist GR73632 to enhance the capsaicin-evoked substance P release in our latest research, which thus demonstrated that the potentiation of capsaicin-evoked substance P release by GR73632 via the activation of neurokinin-1 receptor depends on the activation of PKCs, MEK and p38 MAP kinase, PLC and COXs from cultured DRG neurons (Unpublished data).
Positive_regulation (activation) of PKCs in neurons associated with dorsal root ganglion, qutenza, agonist and substance p
4) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.43 Pain Relevance 1.24

General Comments

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