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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk14, Stat4) nucleus (Mapk14, Stat4) mitochondrion (Mapk14)
cell morphogenesis (Mapk14) DNA binding (Stat4) signal transducer activity (Stat4)
Anatomy Link Frequency
Spinal 1
Mapk14 (Rattus norvegicus)
Stat4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 14 98.44 Very High Very High Very High
Pain 5 97.80 Very High Very High Very High
Spinal cord 9 97.32 Very High Very High Very High
rheumatoid arthritis 29 91.56 High High
Inflammation 15 91.32 High High
gABA 17 72.60 Quite High
Multiple sclerosis 3 30.32 Quite Low
GABA receptor 2 19.84 Low Low
Inflammatory response 5 18.08 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 5 97.80 Very High Very High Very High
Nociception 1 95.24 Very High Very High Very High
Rheumatoid Arthritis 29 91.56 High High
INFLAMMATION 18 91.32 High High
Arthritis 6 81.00 Quite High
Disease 10 63.24 Quite High
Genetic Predisposition To Disease 2 51.40 Quite High
Epilepsy 1 32.80 Quite Low
Sleep Disorders 1 32.40 Quite Low
Schizophrenia 1 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal p38 MAPK which then interacts with STAT4 or other molecules to induce signals that upregulate additional proinflammatory cytokine release such as IL-1, IL-6, or MMP3 in the periphery [4,7].
p38 Binding (interacts) of STAT4 in Spinal associated with cytokine
1) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 0.84 Pain Relevance 0.63

General Comments

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