INT223156

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.79
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, A2m) extracellular region (Il6, A2m) aging (Il6)
enzyme binding (A2m)
Il6 (Rattus norvegicus)
A2m (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 28 99.96 Very High Very High Very High
rheumatoid arthritis 58 94.12 High High
gABA 34 64.32 Quite High
Spinal cord 18 63.92 Quite High
Inflammation 30 51.44 Quite High
Pain 10 34.68 Quite Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 20 100.00 Very High Very High Very High
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Rheumatoid Arthritis 58 94.12 High High
Neurodegenerative Disease 2 91.80 High High
Arthritis 12 51.92 Quite High
INFLAMMATION 36 50.00 Quite Low
Pain 10 34.68 Quite Low
Nociception 2 32.12 Quite Low
General Immunology 8 12.64 Low Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these excessive proinflammatory cytokines, IL-6, is implicated in improper beta-amyloid processing during Alzheimer's disease (AD) due to its effects on alpha-2-macroglobulin (A2M) [25].
IL-6 Regulation (effects) of alpha-2-macroglobulin associated with alzheimer's dementia, disease and cytokine
1) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.40 Pain Relevance 0.70
One of these excessive proinflammatory cytokines, IL-6, is implicated in improper beta-amyloid processing during Alzheimer's disease (AD) due to its effects on alpha-2-macroglobulin (A2M) [25].
IL-6 Regulation (effects) of A2M associated with alzheimer's dementia, disease and cytokine
2) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.40 Pain Relevance 0.70

General Comments

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