INT223283

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (CYP2C9, VKORC1) endoplasmic reticulum (CYP2C9, VKORC1) small molecule metabolic process (CYP2C9)
CYP2C9 (Homo sapiens)
VKORC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 2 39.04 Quite Low
Codeine 2 38.64 Quite Low
beta blocker 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 2 84.00 Quite High
Hepatotoxicity 2 79.36 Quite High
Disease 32 30.24 Quite Low
Cancer 12 5.00 Very Low Very Low Very Low
Lung Cancer 7 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Disease Susceptibility 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More trials in this area are ongoing to test the concept that prospective genotyping of CYP2C9 and VKORC1 in treatment with warfarin and acenocoumarol improves the safety of the patients.
CYP2C9 Binding (genotyping) of VKORC1
1) Confidence 0.31 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.16 Pain Relevance 0

General Comments

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