INT223289

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (H6PD) endoplasmic reticulum (H6PD) carbohydrate metabolic process (H6PD)
H6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 8 5.00 Very Low Very Low Very Low
tramadol 8 5.00 Very Low Very Low Very Low
beta blocker 8 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 8 99.08 Very High Very High Very High
Disease 128 84.88 Quite High
Apnoea 4 74.32 Quite High
Liver Disease 4 41.44 Quite Low
Mycobacterial Infection 4 30.48 Quite Low
Cancer 48 5.00 Very Low Very Low Very Low
Lung Cancer 28 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 20 5.00 Very Low Very Low Very Low
Toxicity 16 5.00 Very Low Very Low Very Low
Hypertension 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A deficiency in the enzyme glucose-6-phosphase dehydrogenase (G6PDH) was identified when about 10% of African American soldiers suffered from haemolysis during treatment with the antimalarial drug primaquine and other drugs, whereas this problem was almost absent in White Americans [2].
Negative_regulation (deficiency) of G6PDH
1) Confidence 0.24 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.12 Pain Relevance 0
However, they are protected from malaria to some extent, and it is well known that the worldwide map of high prevalence of G6PDH deficiency largely overlaps with malaria prevalence.


Negative_regulation (deficiency) of G6PDH associated with malaria
2) Confidence 0.24 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.27 Pain Relevance 0
Electrophilic reactive metabolites of many drugs can only poorly be detoxified in carriers of the x-chromosomally inherited G6PDH deficiency [3].
Negative_regulation (deficiency) of G6PDH
3) Confidence 0.24 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.08 Pain Relevance 0
Nowadays, more than 150 mutations causing G6PDH deficiency are known.
Negative_regulation (deficiency) of G6PDH
4) Confidence 0.24 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.08 Pain Relevance 0

General Comments

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