INT22335

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.01
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
blood 2
brain 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 41 100.00 Very High Very High Very High
Inflammation 54 98.88 Very High Very High Very High
Angina 9 97.92 Very High Very High Very High
Neuropeptide 2 96.76 Very High Very High Very High
cva 11 90.00 High High
aspirin 3 89.24 High High
backache 1 86.92 High High
Calcium channel 2 86.56 High High
headache 2 86.48 High High
beta blocker 5 80.60 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 39 99.96 Very High Very High Very High
Glaucoma 40 99.84 Very High Very High Very High
Cicatrix 3 99.32 Very High Very High Very High
Neurogenic Inflammation 3 99.16 Very High Very High Very High
Diabetic Retinopathy 18 98.88 Very High Very High Very High
Stable Angina Pectoris 2 98.20 Very High Very High Very High
Pathologic Dilatation 50 98.16 Very High Very High Very High
Hypertension 43 97.88 Very High Very High Very High
Ocular Hypertension 24 97.44 Very High Very High Very High
Cognitive Disorder 1 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore explored the effect of specific blockers of NEP and ACE on the intensity of neurogenic inflammation.
Regulation (effect) of Negative_regulation (blockers) of ACE associated with inflammation and neurogenic inflammation
1) Confidence 0.44 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15963503 Disease Relevance 0.38 Pain Relevance 0.29
The major effect of ACE inhibition in cardiac disorders may therefore not be due to inhibition of systemic angiotensin production, but due to reduced tissue angiotensin II activity.


Regulation (effect) of Negative_regulation (inhibition) of ACE
2) Confidence 0.44 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 0.44 Pain Relevance 0.10
responded to statin and ACE inhibitor treatment dramatically and
Regulation (responded) of Negative_regulation (treatment) of ACE
3) Confidence 0.41 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.02 Pain Relevance 0.29
Potential use of ACE inhibitors in glaucoma treatment
Regulation (use) of Negative_regulation (inhibitors) of ACE associated with glaucoma
4) Confidence 0.33 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 1.46 Pain Relevance 0.08
In patients with biventricular cardiac failure, ACE inhibitors have no effect on splanchnic blood flow [123].
Neg (no) Regulation (effect) of Negative_regulation (inhibitors) of ACE in blood associated with myocardial infarction
5) Confidence 0.27 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.92 Pain Relevance 0.12
This drug functions through a novel mechanism of action and has the potential to become a true alternative to angiotensin converting enzyme inhibitors and angiotensin receptor blockers in the therapy of hypertension and other cardiovascular and renal disorders.
Regulation (alternative) of Negative_regulation (inhibitors) of angiotensin converting enzyme associated with renal disease and hypertension
6) Confidence 0.22 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19066408 Disease Relevance 0.60 Pain Relevance 0.21
[Effects of inhibitors of the angiotensin-converting enzyme on endothelial dysfunction in patients with stable angina pectoris].
Regulation ([Effects) of Negative_regulation (inhibitors) of angiotensin-converting enzyme associated with stable angina pectoris and angina
7) Confidence 0.21 Published 2001 Journal Lik. Sprava Section Title Doc Link 11560030 Disease Relevance 0.27 Pain Relevance 0.10
There is little information on the processes affecting selective tissue ACE inhibition and the implications in human subjects.
Regulation (affecting) of Negative_regulation (inhibition) of ACE
8) Confidence 0.20 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.08 Pain Relevance 0.12
An additional evidence of the importance of the bradykinin system in ACE inhibition comes from a study by Guazzi et al (1997).
Regulation (importance) of Negative_regulation (inhibition) of ACE associated with bradykinin
9) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.49 Pain Relevance 0.33
Changes in co-medication during the trial were minimal: in 3 patients (2 in the agalsidase alfa group and one in the agalsidase beta group) a dose change of angiotensin-converting enzyme inhibitor or angiotensin-I blocker was made, and in one patient (agalsidase alfa) an angiotensin-converting enzyme inhibitor was started during the course of the study.
Regulation (change) of Negative_regulation (inhibitor) of angiotensin-converting enzyme
10) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.20 Pain Relevance 0.13
Effects of inhibition of angiotensin converting enzyme (ACE, EC 3.4.15.1) in brain on psychomotor, exploratory, stereotyped and cognitive behaviour in rats were investigated.
Spec (investigated) Regulation (Effects) of Negative_regulation (inhibition) of angiotensin converting enzyme in brain associated with cognitive disorder
11) Confidence 0.04 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2279685 Disease Relevance 0.16 Pain Relevance 0

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