INT22336

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.61
Pain Relevance 6.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
nucleus 14
hypothalamus 5
paraventricular hypothalamic nucleus 2
brain 2
amygdala 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
fluoxetine 12 99.98 Very High Very High Very High
antidepressant 8 99.86 Very High Very High Very High
amygdala 17 99.68 Very High Very High Very High
narcan 7 99.36 Very High Very High Very High
withdrawal 49 98.76 Very High Very High Very High
cocaine 34 98.32 Very High Very High Very High
Serotonin 2 97.80 Very High Very High Very High
depression 4 97.64 Very High Very High Very High
medulla 8 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 43 99.98 Very High Very High Very High
Urological Neuroanatomy 6 98.12 Very High Very High Very High
Anxiety Disorder 2 98.12 Very High Very High Very High
Depression 5 97.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 91.36 High High
Tremor 1 88.56 High High
Substance Withdrawal Syndrome 2 86.88 High High
Pressure Volume 2 Under Development 7 86.40 High High
Aids-related Complex 8 85.36 High High
Opiate Addiction 3 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, there is evidence of enhanced CRF transcription, release, and neuronal activity after the administration of and withdrawal from several drugs of abuse, including cannabis, cocaine, ethanol, and morphine.
Positive_regulation (enhanced) of Transcription (transcription) of CRF in neuronal associated with cannabis, withdrawal, morphine and cocaine
1) Confidence 0.68 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17297634 Disease Relevance 0.46 Pain Relevance 0.49
Concordant with this view is evidence of enhanced CRF transcription, release and activity following withdrawal from several drugs of abuse.
Positive_regulation (enhanced) of Transcription (transcription) of CRF associated with withdrawal
2) Confidence 0.67 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610870 Disease Relevance 0.53 Pain Relevance 0.53
Interestingly, there was no increase of corticotrophin-releasing factor (CRF) mRNA expression in the PVN and central nucleus of the amygdala of Sprague-Dawley rats subjected to the AA treatment.
Neg (no) Positive_regulation (increase) of Transcription (expression) of CRF in nucleus associated with amygdala
3) Confidence 0.66 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.06 Pain Relevance 0.19
In situ hybridization revealed increased corticotrophin releasing hormone (CRH) mRNA expression in the dorsomedial parvocellular paraventricular nucleus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression 4 h after IL-1beta in virgins; these responses were absent in pregnant rats.
Positive_regulation (increased) of Transcription (expression) of CRH in anterior pituitary
4) Confidence 0.64 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917452 Disease Relevance 0 Pain Relevance 0.22
Levels of transcripts for mRNA for both CRF and POMC were markedly reduced after the treatment, but there was a rapid return to control values for CRF mRNA within 18 h of steroid withdrawal.
Positive_regulation (Levels) of Transcription (transcripts) of CRF associated with withdrawal
5) Confidence 0.50 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.13 Pain Relevance 0.08
We asked three questions: first, does corticotropin-releasing hormone (CRH) gene transcription occur in neuroendocrine neurones of the hypothalamic paraventricular nucleus (PVH) of ADX rats, and if so, how is it temporally organized; second, what is the expression pattern of the vasopressin and other genes known to be colocalized in these neuroendocrine neurones; third, if adrenocorticotropin hormone (ACTH) secretion occurs, what is its temporal profile?
Positive_regulation (occur) of Transcription (transcription) of corticotropin-releasing hormone in nucleus
6) Confidence 0.49 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.24 Pain Relevance 0.04
We asked three questions: first, does corticotropin-releasing hormone (CRH) gene transcription occur in neuroendocrine neurones of the hypothalamic paraventricular nucleus (PVH) of ADX rats, and if so, how is it temporally organized; second, what is the expression pattern of the vasopressin and other genes known to be colocalized in these neuroendocrine neurones; third, if adrenocorticotropin hormone (ACTH) secretion occurs, what is its temporal profile?
Positive_regulation (occur) of Transcription (transcription) of CRH in nucleus
7) Confidence 0.49 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.24 Pain Relevance 0.04
Interestingly, there was no increase of corticotrophin-releasing factor (CRF) mRNA expression in the PVN and central nucleus of the amygdala of Sprague-Dawley rats subjected to the AA treatment.
Neg (no) Positive_regulation (increase) of Transcription (expression) of corticotrophin-releasing factor in nucleus associated with amygdala
8) Confidence 0.48 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.06 Pain Relevance 0.19
Thus, while acute stress increases levels of thalamic CRH mRNA, repeated exposure to the same stressor is without effect and prevents the acute response.
Positive_regulation (increases) of Transcription (levels) of CRH associated with stress
9) Confidence 0.47 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.79 Pain Relevance 0.07
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine.
Positive_regulation (Increased) of Transcription (levels) of CRH in amygdala associated with enkephalin, withdrawal, amygdala and cocaine
10) Confidence 0.47 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12782395 Disease Relevance 0.30 Pain Relevance 0.81
There was also a significant elevation of CRH mRNA levels in the amygdala, but not in the hypothalamus, frontal cortex or brainstem after 2-day cocaine withdrawal.
Positive_regulation (elevation) of Transcription (levels) of CRH in hypothalamus associated with medulla, urological neuroanatomy, withdrawal, amygdala and cocaine
11) Confidence 0.47 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.34 Pain Relevance 1.04
In addition, CRF-mRNA levels in the paraventricular hypothalamic nucleus, while reduced in SR141716-treated controls, were significantly increased in Delta(9)-THC-tolerant rats.
Positive_regulation (increased) of Transcription (levels) of CRF in paraventricular hypothalamic nucleus
12) Confidence 0.45 Published 2004 Journal Drug Alcohol Depend Section Abstract Doc Link 15099659 Disease Relevance 0.17 Pain Relevance 0.66
In rats, long-term, daily administration of four different types of clinically effective antidepressant drugs results in decreased corticotropin releasing hormone (CRH) mRNA expression levels in the hypothalamic paraventricular nucleus (PVN).
Positive_regulation (results) of Transcription (expression) of CRH in PVN associated with antidepressant
13) Confidence 0.44 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.28 Pain Relevance 0.25
Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain.
Positive_regulation (induces) of Transcription (transcription) of corticotropin-releasing factor in brain associated with fluoxetine
14) Confidence 0.39 Published 1998 Journal Neuroscience Section Title Doc Link 9740405 Disease Relevance 0.10 Pain Relevance 0.61
A significant increase in CRF mRNA levels in the PVN was observed 120 min after the i.c.v. injection of beta-endorphin.
Positive_regulation (increase) of Transcription (levels) of CRF in PVN
15) Confidence 0.39 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.36
Our results show that a large reduction in extracellular fluid maintained over approximately 20 hours is associated with a significant increase in the level of corticotropin-releasing hormone mRNA in the medial parvicellular division of the paraventricular nucleus.
Positive_regulation (increase) of Transcription (level) of corticotropin-releasing hormone in nucleus
16) Confidence 0.33 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.09 Pain Relevance 0.04
Consistent with previous findings, a 7-day exposure to chronic footshock resulted in a 2.1-fold increase in CRF mRNA levels in the parvocellular division of the PVH.
Positive_regulation (increase) of Transcription (levels) of CRF in PVH
17) Confidence 0.25 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8401558 Disease Relevance 0.32 Pain Relevance 0.25
There was also a significant elevation of CRH mRNA levels in the amygdala, but not in the hypothalamus, frontal cortex or brainstem after 2-day cocaine withdrawal.
Positive_regulation (elevation) of in frontal cortex Transcription (levels) of CRH in hypothalamus associated with medulla, urological neuroanatomy, withdrawal, amygdala and cocaine
18) Confidence 0.16 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.34 Pain Relevance 1.04

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